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Differential MIR-21 Expression in Plasma From Mesenteric Versus Peripheral Veins: An Observational Study of Disease-free Survival in Surgically Resected Colon Cancer Patients
Findings on the role of plasma miR-21 expression in colorectal cancer are contradictory. Before reaching a peripheral vein (PV), microRNAs released by the tumor are dispersed throughout the body. We hypothesized that blood drawn from the mesenteric vein (MV) near the site of the primary tumor could...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602834/ https://www.ncbi.nlm.nih.gov/pubmed/25569638 http://dx.doi.org/10.1097/MD.0000000000000145 |
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author | Monzo, Mariano Martínez-Rodenas, Francisco Moreno, Isabel Navarro, Alfons Santasusagna, Sandra Macias, Ismael Muñoz, Carmen Tejero, Rut Hernández, Raquel |
author_facet | Monzo, Mariano Martínez-Rodenas, Francisco Moreno, Isabel Navarro, Alfons Santasusagna, Sandra Macias, Ismael Muñoz, Carmen Tejero, Rut Hernández, Raquel |
author_sort | Monzo, Mariano |
collection | PubMed |
description | Findings on the role of plasma miR-21 expression in colorectal cancer are contradictory. Before reaching a peripheral vein (PV), microRNAs released by the tumor are dispersed throughout the body. We hypothesized that blood drawn from the mesenteric vein (MV) near the site of the primary tumor could provide more homogeneous information than blood drawn from the PV. We have analyzed miR-21 expression in matched samples of tumor tissue, normal tissue, MV plasma, and PV plasma in 57 surgically resected patients with colon cancer and correlated our findings with clinical characteristics and disease-free survival (DFS). miR-21 expression was higher in MV than PV plasma (P = 0.014) and in tumor than in normal tissue (P < 0.001). Patients with high levels of miR-21 in MV plasma had shorter DFS (P = 0.05) than those with low levels, and those with high levels in both MV and PV plasma had shorter DFS than all other patients (P = 0.01). Our findings suggest that the primary tumor in colon cancer releases high concentrations of miR-21 in the MV but that these concentrations are later diluted in the circulatory system. MV expression of miR-21 may be a stronger prognostic marker than PV expression. |
format | Online Article Text |
id | pubmed-4602834 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-46028342015-10-27 Differential MIR-21 Expression in Plasma From Mesenteric Versus Peripheral Veins: An Observational Study of Disease-free Survival in Surgically Resected Colon Cancer Patients Monzo, Mariano Martínez-Rodenas, Francisco Moreno, Isabel Navarro, Alfons Santasusagna, Sandra Macias, Ismael Muñoz, Carmen Tejero, Rut Hernández, Raquel Medicine (Baltimore) 5700 Findings on the role of plasma miR-21 expression in colorectal cancer are contradictory. Before reaching a peripheral vein (PV), microRNAs released by the tumor are dispersed throughout the body. We hypothesized that blood drawn from the mesenteric vein (MV) near the site of the primary tumor could provide more homogeneous information than blood drawn from the PV. We have analyzed miR-21 expression in matched samples of tumor tissue, normal tissue, MV plasma, and PV plasma in 57 surgically resected patients with colon cancer and correlated our findings with clinical characteristics and disease-free survival (DFS). miR-21 expression was higher in MV than PV plasma (P = 0.014) and in tumor than in normal tissue (P < 0.001). Patients with high levels of miR-21 in MV plasma had shorter DFS (P = 0.05) than those with low levels, and those with high levels in both MV and PV plasma had shorter DFS than all other patients (P = 0.01). Our findings suggest that the primary tumor in colon cancer releases high concentrations of miR-21 in the MV but that these concentrations are later diluted in the circulatory system. MV expression of miR-21 may be a stronger prognostic marker than PV expression. Wolters Kluwer Health 2015-01-09 /pmc/articles/PMC4602834/ /pubmed/25569638 http://dx.doi.org/10.1097/MD.0000000000000145 Text en Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0, where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/4.0 |
spellingShingle | 5700 Monzo, Mariano Martínez-Rodenas, Francisco Moreno, Isabel Navarro, Alfons Santasusagna, Sandra Macias, Ismael Muñoz, Carmen Tejero, Rut Hernández, Raquel Differential MIR-21 Expression in Plasma From Mesenteric Versus Peripheral Veins: An Observational Study of Disease-free Survival in Surgically Resected Colon Cancer Patients |
title | Differential MIR-21 Expression in Plasma From Mesenteric Versus Peripheral Veins: An Observational Study of Disease-free Survival in Surgically Resected Colon Cancer Patients |
title_full | Differential MIR-21 Expression in Plasma From Mesenteric Versus Peripheral Veins: An Observational Study of Disease-free Survival in Surgically Resected Colon Cancer Patients |
title_fullStr | Differential MIR-21 Expression in Plasma From Mesenteric Versus Peripheral Veins: An Observational Study of Disease-free Survival in Surgically Resected Colon Cancer Patients |
title_full_unstemmed | Differential MIR-21 Expression in Plasma From Mesenteric Versus Peripheral Veins: An Observational Study of Disease-free Survival in Surgically Resected Colon Cancer Patients |
title_short | Differential MIR-21 Expression in Plasma From Mesenteric Versus Peripheral Veins: An Observational Study of Disease-free Survival in Surgically Resected Colon Cancer Patients |
title_sort | differential mir-21 expression in plasma from mesenteric versus peripheral veins: an observational study of disease-free survival in surgically resected colon cancer patients |
topic | 5700 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602834/ https://www.ncbi.nlm.nih.gov/pubmed/25569638 http://dx.doi.org/10.1097/MD.0000000000000145 |
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