Cyclosporine for the Treatment of HTLV-1-Induced HAM/TSP: An Experience from a Case Report

HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) remains a challenging disease. Treatment options are scarce, and their safety and efficacy are currently a matter of concern. We present a case report describing our experience using cyclosporine in a patient with early HAM/TSP who...

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Autores principales: Sánchez-Montalvá, Adrián, Salvador, Fernando, Caballero, Estrella, Molina, Israel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2015
Materias:
4900
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602838/
https://www.ncbi.nlm.nih.gov/pubmed/25569667
http://dx.doi.org/10.1097/MD.0000000000000382
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author Sánchez-Montalvá, Adrián
Salvador, Fernando
Caballero, Estrella
Molina, Israel
author_facet Sánchez-Montalvá, Adrián
Salvador, Fernando
Caballero, Estrella
Molina, Israel
author_sort Sánchez-Montalvá, Adrián
collection PubMed
description HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) remains a challenging disease. Treatment options are scarce, and their safety and efficacy are currently a matter of concern. We present a case report describing our experience using cyclosporine in a patient with early HAM/TSP who started with a gait disturbance at Vall d’Hebron University Hospital (Barcelona) from August 2012 to October 2013. After 62 weeks of treatment, clinical improvement was observed and proviral load diminished. No safety concerns were observed. Cyclosporine seems to be effective in new-onset HAM/TSP or in chronic HAM/TSP that develops a relapse. However, the duration and safety profile of this steroid-sparing therapy remain unknown and should be further investigated.
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spelling pubmed-46028382015-10-27 Cyclosporine for the Treatment of HTLV-1-Induced HAM/TSP: An Experience from a Case Report Sánchez-Montalvá, Adrián Salvador, Fernando Caballero, Estrella Molina, Israel Medicine (Baltimore) 4900 HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) remains a challenging disease. Treatment options are scarce, and their safety and efficacy are currently a matter of concern. We present a case report describing our experience using cyclosporine in a patient with early HAM/TSP who started with a gait disturbance at Vall d’Hebron University Hospital (Barcelona) from August 2012 to October 2013. After 62 weeks of treatment, clinical improvement was observed and proviral load diminished. No safety concerns were observed. Cyclosporine seems to be effective in new-onset HAM/TSP or in chronic HAM/TSP that develops a relapse. However, the duration and safety profile of this steroid-sparing therapy remain unknown and should be further investigated. Wolters Kluwer Health 2015-01-09 /pmc/articles/PMC4602838/ /pubmed/25569667 http://dx.doi.org/10.1097/MD.0000000000000382 Text en Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle 4900
Sánchez-Montalvá, Adrián
Salvador, Fernando
Caballero, Estrella
Molina, Israel
Cyclosporine for the Treatment of HTLV-1-Induced HAM/TSP: An Experience from a Case Report
title Cyclosporine for the Treatment of HTLV-1-Induced HAM/TSP: An Experience from a Case Report
title_full Cyclosporine for the Treatment of HTLV-1-Induced HAM/TSP: An Experience from a Case Report
title_fullStr Cyclosporine for the Treatment of HTLV-1-Induced HAM/TSP: An Experience from a Case Report
title_full_unstemmed Cyclosporine for the Treatment of HTLV-1-Induced HAM/TSP: An Experience from a Case Report
title_short Cyclosporine for the Treatment of HTLV-1-Induced HAM/TSP: An Experience from a Case Report
title_sort cyclosporine for the treatment of htlv-1-induced ham/tsp: an experience from a case report
topic 4900
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602838/
https://www.ncbi.nlm.nih.gov/pubmed/25569667
http://dx.doi.org/10.1097/MD.0000000000000382
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