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Synchronous Hepatic Epithelioid Hemangioendothelioma and Hepatocellular Carcinoma: First Case Report in the Literature and Challenges

We would like to report the first case in English literature, to the best of our knowledge, of a synchronous hepatic epithelioid hemangioendothelioma (HEHE) and hepatocellular carcinoma (HCC), as well as to address the current trends and challenges in the management of HEHE. An otherwise well 58-yea...

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Autores principales: Athanasopoulos, Panagiotis G., Hadjittofi, Christopher, Luong, Tu Vinh, O’Beirne, James, Sharma, Dinesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602905/
https://www.ncbi.nlm.nih.gov/pubmed/26313777
http://dx.doi.org/10.1097/MD.0000000000001377
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author Athanasopoulos, Panagiotis G.
Hadjittofi, Christopher
Luong, Tu Vinh
O’Beirne, James
Sharma, Dinesh
author_facet Athanasopoulos, Panagiotis G.
Hadjittofi, Christopher
Luong, Tu Vinh
O’Beirne, James
Sharma, Dinesh
author_sort Athanasopoulos, Panagiotis G.
collection PubMed
description We would like to report the first case in English literature, to the best of our knowledge, of a synchronous hepatic epithelioid hemangioendothelioma (HEHE) and hepatocellular carcinoma (HCC), as well as to address the current trends and challenges in the management of HEHE. An otherwise well 58-year-old man was referred to his local hepatology service with elevated serum γ-GT levels. Imaging revealed bilobar liver lesions consistent with HEHE, a discrete left lobe lesion suspected as HCC, and multiple pulmonary nodules. Biopsies confirmed HEHE with pulmonary metastases. After multidisciplinary team discussions, the patient was admitted under our team and underwent an uneventful laparoscopic left lateral hepatectomy for suspected HCC, which was confirmed histologically. As part of a watch-and-wait approach to metastatic HEHE, in the first follow-up (3 months postoperatively) the patient was clinically fine and the surveillance CT scan did not show recurrent disease. By presenting this case, we aim to raise awareness that this rare entity can coexist with others, potentially complicating their management.
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spelling pubmed-46029052015-10-27 Synchronous Hepatic Epithelioid Hemangioendothelioma and Hepatocellular Carcinoma: First Case Report in the Literature and Challenges Athanasopoulos, Panagiotis G. Hadjittofi, Christopher Luong, Tu Vinh O’Beirne, James Sharma, Dinesh Medicine (Baltimore) 7100 We would like to report the first case in English literature, to the best of our knowledge, of a synchronous hepatic epithelioid hemangioendothelioma (HEHE) and hepatocellular carcinoma (HCC), as well as to address the current trends and challenges in the management of HEHE. An otherwise well 58-year-old man was referred to his local hepatology service with elevated serum γ-GT levels. Imaging revealed bilobar liver lesions consistent with HEHE, a discrete left lobe lesion suspected as HCC, and multiple pulmonary nodules. Biopsies confirmed HEHE with pulmonary metastases. After multidisciplinary team discussions, the patient was admitted under our team and underwent an uneventful laparoscopic left lateral hepatectomy for suspected HCC, which was confirmed histologically. As part of a watch-and-wait approach to metastatic HEHE, in the first follow-up (3 months postoperatively) the patient was clinically fine and the surveillance CT scan did not show recurrent disease. By presenting this case, we aim to raise awareness that this rare entity can coexist with others, potentially complicating their management. Wolters Kluwer Health 2015-08-28 /pmc/articles/PMC4602905/ /pubmed/26313777 http://dx.doi.org/10.1097/MD.0000000000001377 Text en Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0, where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/4.0
spellingShingle 7100
Athanasopoulos, Panagiotis G.
Hadjittofi, Christopher
Luong, Tu Vinh
O’Beirne, James
Sharma, Dinesh
Synchronous Hepatic Epithelioid Hemangioendothelioma and Hepatocellular Carcinoma: First Case Report in the Literature and Challenges
title Synchronous Hepatic Epithelioid Hemangioendothelioma and Hepatocellular Carcinoma: First Case Report in the Literature and Challenges
title_full Synchronous Hepatic Epithelioid Hemangioendothelioma and Hepatocellular Carcinoma: First Case Report in the Literature and Challenges
title_fullStr Synchronous Hepatic Epithelioid Hemangioendothelioma and Hepatocellular Carcinoma: First Case Report in the Literature and Challenges
title_full_unstemmed Synchronous Hepatic Epithelioid Hemangioendothelioma and Hepatocellular Carcinoma: First Case Report in the Literature and Challenges
title_short Synchronous Hepatic Epithelioid Hemangioendothelioma and Hepatocellular Carcinoma: First Case Report in the Literature and Challenges
title_sort synchronous hepatic epithelioid hemangioendothelioma and hepatocellular carcinoma: first case report in the literature and challenges
topic 7100
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602905/
https://www.ncbi.nlm.nih.gov/pubmed/26313777
http://dx.doi.org/10.1097/MD.0000000000001377
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