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Primary Indeterminate Dendritic Cell Tumor of Skin Correlated to Mosquito Bite

Primary indeterminate dendritic cell tumor (IDCT) is an extremely neoplastic dendritic cell disorder. Little is known about its pathogenesis, etiology, and prognostic factors because of its rarity. Herein, we present a case report of a skin IDCT that arose in mosquito bite and discuss the correlatio...

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Autores principales: Mo, Xianglan, Guo, Wenwen, Ye, Hongtao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602924/
https://www.ncbi.nlm.nih.gov/pubmed/26313805
http://dx.doi.org/10.1097/MD.0000000000001443
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author Mo, Xianglan
Guo, Wenwen
Ye, Hongtao
author_facet Mo, Xianglan
Guo, Wenwen
Ye, Hongtao
author_sort Mo, Xianglan
collection PubMed
description Primary indeterminate dendritic cell tumor (IDCT) is an extremely neoplastic dendritic cell disorder. Little is known about its pathogenesis, etiology, and prognostic factors because of its rarity. Herein, we present a case report of a skin IDCT that arose in mosquito bite and discuss the correlation between hypersensitivity to mosquito bites and leukemia/lymphoma. A 28-year old man presented with multiple widespread cutaneous plaques and nodules 8 months after being bitten by a mosquito on his back. Dermatological examination revealed multiple skin-colored, well-demarcated plaques and nodules measuring approximately 0.5 to 1.8 cm in diameter all over the body. A biopsy of the skin lesion was taken. Morphologically, the dermis was effaced by round or polygonal cells with oval nuclei and abundant eosinophilic cytoplasm, arranged in nests and in some areas in a sheet-like pattern. The tumor cells were positive for CD68, CD1a, and S-100, whereas negative for Langerin and lack Birbeck granules ultrastructurally. A diagnosis of IDCT was made. No treatment was given. The patient was alive with spontaneous disease regression after 17 months of follow-up. IDCT is an extremely rare disease and may be associated with mosquito bite.
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spelling pubmed-46029242015-10-27 Primary Indeterminate Dendritic Cell Tumor of Skin Correlated to Mosquito Bite Mo, Xianglan Guo, Wenwen Ye, Hongtao Medicine (Baltimore) 4000 Primary indeterminate dendritic cell tumor (IDCT) is an extremely neoplastic dendritic cell disorder. Little is known about its pathogenesis, etiology, and prognostic factors because of its rarity. Herein, we present a case report of a skin IDCT that arose in mosquito bite and discuss the correlation between hypersensitivity to mosquito bites and leukemia/lymphoma. A 28-year old man presented with multiple widespread cutaneous plaques and nodules 8 months after being bitten by a mosquito on his back. Dermatological examination revealed multiple skin-colored, well-demarcated plaques and nodules measuring approximately 0.5 to 1.8 cm in diameter all over the body. A biopsy of the skin lesion was taken. Morphologically, the dermis was effaced by round or polygonal cells with oval nuclei and abundant eosinophilic cytoplasm, arranged in nests and in some areas in a sheet-like pattern. The tumor cells were positive for CD68, CD1a, and S-100, whereas negative for Langerin and lack Birbeck granules ultrastructurally. A diagnosis of IDCT was made. No treatment was given. The patient was alive with spontaneous disease regression after 17 months of follow-up. IDCT is an extremely rare disease and may be associated with mosquito bite. Wolters Kluwer Health 2015-08-28 /pmc/articles/PMC4602924/ /pubmed/26313805 http://dx.doi.org/10.1097/MD.0000000000001443 Text en Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0, where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/4.0
spellingShingle 4000
Mo, Xianglan
Guo, Wenwen
Ye, Hongtao
Primary Indeterminate Dendritic Cell Tumor of Skin Correlated to Mosquito Bite
title Primary Indeterminate Dendritic Cell Tumor of Skin Correlated to Mosquito Bite
title_full Primary Indeterminate Dendritic Cell Tumor of Skin Correlated to Mosquito Bite
title_fullStr Primary Indeterminate Dendritic Cell Tumor of Skin Correlated to Mosquito Bite
title_full_unstemmed Primary Indeterminate Dendritic Cell Tumor of Skin Correlated to Mosquito Bite
title_short Primary Indeterminate Dendritic Cell Tumor of Skin Correlated to Mosquito Bite
title_sort primary indeterminate dendritic cell tumor of skin correlated to mosquito bite
topic 4000
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602924/
https://www.ncbi.nlm.nih.gov/pubmed/26313805
http://dx.doi.org/10.1097/MD.0000000000001443
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