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Study of the Histopathologic Characteristics and Surface Morphologies of Glottic Carcinomas With Anterior Vocal Commissure Involvement

This article explores the features and the role of the anterior vocal commissure (AVC) structure and the surface morphologies of glottic carcinomas with AVC involvement to provide a reference for the selection of transoral carbon dioxide (CO(2)) laser surgery. A total of 31 cases of glottic carcinom...

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Autores principales: Wu, Jianhui, Zhao, Jing, Wang, Zhangfeng, Li, Zenghong, Luo, Jie, Liao, Bing, Yang, Zhiyun, Liu, Qihong, Wang, Bin, Wen, Weiping, Lei, Wenbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603010/
https://www.ncbi.nlm.nih.gov/pubmed/26200618
http://dx.doi.org/10.1097/MD.0000000000001169
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author Wu, Jianhui
Zhao, Jing
Wang, Zhangfeng
Li, Zenghong
Luo, Jie
Liao, Bing
Yang, Zhiyun
Liu, Qihong
Wang, Bin
Wen, Weiping
Lei, Wenbin
author_facet Wu, Jianhui
Zhao, Jing
Wang, Zhangfeng
Li, Zenghong
Luo, Jie
Liao, Bing
Yang, Zhiyun
Liu, Qihong
Wang, Bin
Wen, Weiping
Lei, Wenbin
author_sort Wu, Jianhui
collection PubMed
description This article explores the features and the role of the anterior vocal commissure (AVC) structure and the surface morphologies of glottic carcinomas with AVC involvement to provide a reference for the selection of transoral carbon dioxide (CO(2)) laser surgery. A total of 31 cases of glottic carcinomas with AVC involvement from May 2012 to January 2014 were included. All patients underwent electronic laryngoscopic examinations and computed tomography scans to determine the surface morphology. After surgery, the tumor specimens were resected integrally, and axial serial sections parallel to the plane of vocal cords were taken to explore the features and possible invasion paths of the glottic carcinomas with AVC involvement. The rates of involvement of the supraglottis and subglottis were 71.4% and 14.8%, respectively, via the AVC. The involvement of the superficial layer of the unilateral or bilateral vocal cords without involvement of the vocal muscle in the AVC region (IVM) or the cartilage was present in 15 cases (48.4%). The involvement of the superficial layer of the unilateral and bilateral vocal cords occurred in 16 cases (51.6%) with the IVM in 13 cases and the involvement of the intermediate lamina of the thyroid cartilage (ITC) in 8 cases. The involvement of the ITC was associated with the involvement of the vocal muscle of the AVC region (P < 0.05). Among the pushing carcinomas, 15 of 21 (71.4%) presented with well-defined tumor mass, and 8 of 10 (80.0%) infiltrating carcinomas presented with multiple tumor nests that were often surrounded by fibrosis (P < 0.05). The AVC is an important path of invasion of subglottic in glottic carcinomas but less so for suparglottic. The Broyles’ ligaments acted as a barrier against the spread of the tumors to the thyroid cartilage, but this role was obviously weaken by the involvement of the vocal muscle of the AVC region. The infiltrating carcinomas presented with multiple tumor nests in fibrous tissue. When CO(2) laser microsurgery is considered as a treatment option, these facts should be kept in mind.
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spelling pubmed-46030102015-10-27 Study of the Histopathologic Characteristics and Surface Morphologies of Glottic Carcinomas With Anterior Vocal Commissure Involvement Wu, Jianhui Zhao, Jing Wang, Zhangfeng Li, Zenghong Luo, Jie Liao, Bing Yang, Zhiyun Liu, Qihong Wang, Bin Wen, Weiping Lei, Wenbin Medicine (Baltimore) 6000 This article explores the features and the role of the anterior vocal commissure (AVC) structure and the surface morphologies of glottic carcinomas with AVC involvement to provide a reference for the selection of transoral carbon dioxide (CO(2)) laser surgery. A total of 31 cases of glottic carcinomas with AVC involvement from May 2012 to January 2014 were included. All patients underwent electronic laryngoscopic examinations and computed tomography scans to determine the surface morphology. After surgery, the tumor specimens were resected integrally, and axial serial sections parallel to the plane of vocal cords were taken to explore the features and possible invasion paths of the glottic carcinomas with AVC involvement. The rates of involvement of the supraglottis and subglottis were 71.4% and 14.8%, respectively, via the AVC. The involvement of the superficial layer of the unilateral or bilateral vocal cords without involvement of the vocal muscle in the AVC region (IVM) or the cartilage was present in 15 cases (48.4%). The involvement of the superficial layer of the unilateral and bilateral vocal cords occurred in 16 cases (51.6%) with the IVM in 13 cases and the involvement of the intermediate lamina of the thyroid cartilage (ITC) in 8 cases. The involvement of the ITC was associated with the involvement of the vocal muscle of the AVC region (P < 0.05). Among the pushing carcinomas, 15 of 21 (71.4%) presented with well-defined tumor mass, and 8 of 10 (80.0%) infiltrating carcinomas presented with multiple tumor nests that were often surrounded by fibrosis (P < 0.05). The AVC is an important path of invasion of subglottic in glottic carcinomas but less so for suparglottic. The Broyles’ ligaments acted as a barrier against the spread of the tumors to the thyroid cartilage, but this role was obviously weaken by the involvement of the vocal muscle of the AVC region. The infiltrating carcinomas presented with multiple tumor nests in fibrous tissue. When CO(2) laser microsurgery is considered as a treatment option, these facts should be kept in mind. Wolters Kluwer Health 2015-07-24 /pmc/articles/PMC4603010/ /pubmed/26200618 http://dx.doi.org/10.1097/MD.0000000000001169 Text en Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle 6000
Wu, Jianhui
Zhao, Jing
Wang, Zhangfeng
Li, Zenghong
Luo, Jie
Liao, Bing
Yang, Zhiyun
Liu, Qihong
Wang, Bin
Wen, Weiping
Lei, Wenbin
Study of the Histopathologic Characteristics and Surface Morphologies of Glottic Carcinomas With Anterior Vocal Commissure Involvement
title Study of the Histopathologic Characteristics and Surface Morphologies of Glottic Carcinomas With Anterior Vocal Commissure Involvement
title_full Study of the Histopathologic Characteristics and Surface Morphologies of Glottic Carcinomas With Anterior Vocal Commissure Involvement
title_fullStr Study of the Histopathologic Characteristics and Surface Morphologies of Glottic Carcinomas With Anterior Vocal Commissure Involvement
title_full_unstemmed Study of the Histopathologic Characteristics and Surface Morphologies of Glottic Carcinomas With Anterior Vocal Commissure Involvement
title_short Study of the Histopathologic Characteristics and Surface Morphologies of Glottic Carcinomas With Anterior Vocal Commissure Involvement
title_sort study of the histopathologic characteristics and surface morphologies of glottic carcinomas with anterior vocal commissure involvement
topic 6000
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603010/
https://www.ncbi.nlm.nih.gov/pubmed/26200618
http://dx.doi.org/10.1097/MD.0000000000001169
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