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Diagnostic Ability of FDG-PET/CT in the Detection of Malignant Pleural Effusion
We investigated the role of F-18 fluorodeoxyglucose (FDG)-positron emission tomography (PET)/computed tomography (CT) for the differential diagnosis of malignant and benign pleural effusion. We studied 36 consecutive patients with histologically proven cancer (excluding malignant mesothelioma) who u...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Wolters Kluwer Health
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603013/ https://www.ncbi.nlm.nih.gov/pubmed/26200610 http://dx.doi.org/10.1097/MD.0000000000001010 |
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author | Nakajima, Reiko Abe, Koichiro Sakai, Shuji |
author_facet | Nakajima, Reiko Abe, Koichiro Sakai, Shuji |
author_sort | Nakajima, Reiko |
collection | PubMed |
description | We investigated the role of F-18 fluorodeoxyglucose (FDG)-positron emission tomography (PET)/computed tomography (CT) for the differential diagnosis of malignant and benign pleural effusion. We studied 36 consecutive patients with histologically proven cancer (excluding malignant mesothelioma) who underwent FDG-PET/CT for suspected malignant pleural effusion. Fourteen patients had cytologically proven malignant pleural effusion and the other 22 patients had either negative cytology or clinical follow-up, which confirmed the benign etiology. We examined the maximum standardized uptake values (SUVmax) of pleural effusion and the target-to-normal tissue ratio (TNR), calculated as the ratio of the pleural effusion SUVmax to the SUVmean of the normal tissues (liver, spleen, 12th thoracic vertebrae [Th12], thoracic aorta, and spinalis muscle). We also examined the size and density (in Hounsfield units) of the pleural effusion and pleural abnormalities on CT images. TNR (Th12) and increased pleural FDG uptake compared to background blood pool were significantly more frequent in cases with malignant pleural effusion (P < 0.05 for both). The cutoff TNR (Th12) value of >0.95 was the most accurate; the sensitivity, specificity, and accuracy for this value were 93%, 68%, and 75%, respectively. FDG-PET/CT can be a useful method for the differential diagnosis of malignant and benign pleural effusion. |
format | Online Article Text |
id | pubmed-4603013 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-46030132015-10-27 Diagnostic Ability of FDG-PET/CT in the Detection of Malignant Pleural Effusion Nakajima, Reiko Abe, Koichiro Sakai, Shuji Medicine (Baltimore) 6800 We investigated the role of F-18 fluorodeoxyglucose (FDG)-positron emission tomography (PET)/computed tomography (CT) for the differential diagnosis of malignant and benign pleural effusion. We studied 36 consecutive patients with histologically proven cancer (excluding malignant mesothelioma) who underwent FDG-PET/CT for suspected malignant pleural effusion. Fourteen patients had cytologically proven malignant pleural effusion and the other 22 patients had either negative cytology or clinical follow-up, which confirmed the benign etiology. We examined the maximum standardized uptake values (SUVmax) of pleural effusion and the target-to-normal tissue ratio (TNR), calculated as the ratio of the pleural effusion SUVmax to the SUVmean of the normal tissues (liver, spleen, 12th thoracic vertebrae [Th12], thoracic aorta, and spinalis muscle). We also examined the size and density (in Hounsfield units) of the pleural effusion and pleural abnormalities on CT images. TNR (Th12) and increased pleural FDG uptake compared to background blood pool were significantly more frequent in cases with malignant pleural effusion (P < 0.05 for both). The cutoff TNR (Th12) value of >0.95 was the most accurate; the sensitivity, specificity, and accuracy for this value were 93%, 68%, and 75%, respectively. FDG-PET/CT can be a useful method for the differential diagnosis of malignant and benign pleural effusion. Wolters Kluwer Health 2015-07-24 /pmc/articles/PMC4603013/ /pubmed/26200610 http://dx.doi.org/10.1097/MD.0000000000001010 Text en Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the Creative Commons Attribution-NonCommercial License, where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be used commercially. http://creativecommons.org/licenses/by-nc/4.0 |
spellingShingle | 6800 Nakajima, Reiko Abe, Koichiro Sakai, Shuji Diagnostic Ability of FDG-PET/CT in the Detection of Malignant Pleural Effusion |
title | Diagnostic Ability of FDG-PET/CT in the Detection of Malignant Pleural Effusion |
title_full | Diagnostic Ability of FDG-PET/CT in the Detection of Malignant Pleural Effusion |
title_fullStr | Diagnostic Ability of FDG-PET/CT in the Detection of Malignant Pleural Effusion |
title_full_unstemmed | Diagnostic Ability of FDG-PET/CT in the Detection of Malignant Pleural Effusion |
title_short | Diagnostic Ability of FDG-PET/CT in the Detection of Malignant Pleural Effusion |
title_sort | diagnostic ability of fdg-pet/ct in the detection of malignant pleural effusion |
topic | 6800 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603013/ https://www.ncbi.nlm.nih.gov/pubmed/26200610 http://dx.doi.org/10.1097/MD.0000000000001010 |
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