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Fruits and Vegetables Intake and Risk of Bladder Cancer: A PRISMA-Compliant Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies
Clinical practice recommends eating ≥2.5 cups of fruits and vegetables (FVs) each day for cancer prevention, in which the evidence from epidemiological studies for the association between FVs intake and bladder cancer (BC) prevention is inconsistent. We searched the PubMed, Embase, and Willy online...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603065/ https://www.ncbi.nlm.nih.gov/pubmed/25929912 http://dx.doi.org/10.1097/MD.0000000000000759 |
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author | Xu, Chang Zeng, Xian-Tao Liu, Tong-Zu Zhang, Chao Yang, Zhong-Hua Li, Sheng Chen, Xiao-Yan |
author_facet | Xu, Chang Zeng, Xian-Tao Liu, Tong-Zu Zhang, Chao Yang, Zhong-Hua Li, Sheng Chen, Xiao-Yan |
author_sort | Xu, Chang |
collection | PubMed |
description | Clinical practice recommends eating ≥2.5 cups of fruits and vegetables (FVs) each day for cancer prevention, in which the evidence from epidemiological studies for the association between FVs intake and bladder cancer (BC) prevention is inconsistent. We searched the PubMed, Embase, and Willy online Library for relevant studies published up to September 27, 2014. Prospective cohort studies investigated FVs intake, and the risk of BC with ≥3 categories of exposure was included. A dose-response meta-analysis was carried out to evaluate the association between FVs intake and risk of BC. Fourteen cohorts with 17 studies including 9447 cases were identified. No evidence of nonlinear association was examined between FVs intake and risk of BC. The summarized relevant risk (RR) of every 0.2 serving increment a day was 1.00 (95%CI: 0.99, 1.00; P = 0.17; I(2) = 41.7%; n = 14) for total fruits; 0.99 (95%CI: 0.96, 1.01; P = 0.28; I(2) = 37.0%; n = 13) for total vegetables; and 0.99 (95%CI: 0.97, 1.01; P = 0.24; I(2) = 57.5%; n = 8) for both FVs. In further analysis, we observed inverse association between every 0.2 serving increment of green leafy vegetables intake a day and risk of BC (RR = 0.98, 95%CI: 0.96, 0.99; I(2) = 0.0%; P < 0.01; Power = 0.76; n = 6), but neither for cruciferous vegetables (RR = 0.97, 95%CI: 0.93, 1.01; P = 0.19; I(2) = 55.8%; n = 8) nor for citrus (RR = 1.00, 95%CI: 1.00, 1.00; P = 0.83; I(2) = 0.0%; n = 7). Subgroup analysis showed consistent results. Little evidence supports a beneficial effect for total fruits, vegetables, both FVs, and citrus intake against bladder cancer. Green leafy vegetables may help prevent bladder cancer. |
format | Online Article Text |
id | pubmed-4603065 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-46030652015-10-27 Fruits and Vegetables Intake and Risk of Bladder Cancer: A PRISMA-Compliant Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies Xu, Chang Zeng, Xian-Tao Liu, Tong-Zu Zhang, Chao Yang, Zhong-Hua Li, Sheng Chen, Xiao-Yan Medicine (Baltimore) 7300 Clinical practice recommends eating ≥2.5 cups of fruits and vegetables (FVs) each day for cancer prevention, in which the evidence from epidemiological studies for the association between FVs intake and bladder cancer (BC) prevention is inconsistent. We searched the PubMed, Embase, and Willy online Library for relevant studies published up to September 27, 2014. Prospective cohort studies investigated FVs intake, and the risk of BC with ≥3 categories of exposure was included. A dose-response meta-analysis was carried out to evaluate the association between FVs intake and risk of BC. Fourteen cohorts with 17 studies including 9447 cases were identified. No evidence of nonlinear association was examined between FVs intake and risk of BC. The summarized relevant risk (RR) of every 0.2 serving increment a day was 1.00 (95%CI: 0.99, 1.00; P = 0.17; I(2) = 41.7%; n = 14) for total fruits; 0.99 (95%CI: 0.96, 1.01; P = 0.28; I(2) = 37.0%; n = 13) for total vegetables; and 0.99 (95%CI: 0.97, 1.01; P = 0.24; I(2) = 57.5%; n = 8) for both FVs. In further analysis, we observed inverse association between every 0.2 serving increment of green leafy vegetables intake a day and risk of BC (RR = 0.98, 95%CI: 0.96, 0.99; I(2) = 0.0%; P < 0.01; Power = 0.76; n = 6), but neither for cruciferous vegetables (RR = 0.97, 95%CI: 0.93, 1.01; P = 0.19; I(2) = 55.8%; n = 8) nor for citrus (RR = 1.00, 95%CI: 1.00, 1.00; P = 0.83; I(2) = 0.0%; n = 7). Subgroup analysis showed consistent results. Little evidence supports a beneficial effect for total fruits, vegetables, both FVs, and citrus intake against bladder cancer. Green leafy vegetables may help prevent bladder cancer. Wolters Kluwer Health 2015-05-01 /pmc/articles/PMC4603065/ /pubmed/25929912 http://dx.doi.org/10.1097/MD.0000000000000759 Text en Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0, where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/4.0 |
spellingShingle | 7300 Xu, Chang Zeng, Xian-Tao Liu, Tong-Zu Zhang, Chao Yang, Zhong-Hua Li, Sheng Chen, Xiao-Yan Fruits and Vegetables Intake and Risk of Bladder Cancer: A PRISMA-Compliant Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies |
title | Fruits and Vegetables Intake and Risk of Bladder Cancer: A PRISMA-Compliant Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies |
title_full | Fruits and Vegetables Intake and Risk of Bladder Cancer: A PRISMA-Compliant Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies |
title_fullStr | Fruits and Vegetables Intake and Risk of Bladder Cancer: A PRISMA-Compliant Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies |
title_full_unstemmed | Fruits and Vegetables Intake and Risk of Bladder Cancer: A PRISMA-Compliant Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies |
title_short | Fruits and Vegetables Intake and Risk of Bladder Cancer: A PRISMA-Compliant Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies |
title_sort | fruits and vegetables intake and risk of bladder cancer: a prisma-compliant systematic review and dose-response meta-analysis of prospective cohort studies |
topic | 7300 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603065/ https://www.ncbi.nlm.nih.gov/pubmed/25929912 http://dx.doi.org/10.1097/MD.0000000000000759 |
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