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Fruits and Vegetables Intake and Risk of Bladder Cancer: A PRISMA-Compliant Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies

Clinical practice recommends eating ≥2.5 cups of fruits and vegetables (FVs) each day for cancer prevention, in which the evidence from epidemiological studies for the association between FVs intake and bladder cancer (BC) prevention is inconsistent. We searched the PubMed, Embase, and Willy online...

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Autores principales: Xu, Chang, Zeng, Xian-Tao, Liu, Tong-Zu, Zhang, Chao, Yang, Zhong-Hua, Li, Sheng, Chen, Xiao-Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603065/
https://www.ncbi.nlm.nih.gov/pubmed/25929912
http://dx.doi.org/10.1097/MD.0000000000000759
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author Xu, Chang
Zeng, Xian-Tao
Liu, Tong-Zu
Zhang, Chao
Yang, Zhong-Hua
Li, Sheng
Chen, Xiao-Yan
author_facet Xu, Chang
Zeng, Xian-Tao
Liu, Tong-Zu
Zhang, Chao
Yang, Zhong-Hua
Li, Sheng
Chen, Xiao-Yan
author_sort Xu, Chang
collection PubMed
description Clinical practice recommends eating ≥2.5 cups of fruits and vegetables (FVs) each day for cancer prevention, in which the evidence from epidemiological studies for the association between FVs intake and bladder cancer (BC) prevention is inconsistent. We searched the PubMed, Embase, and Willy online Library for relevant studies published up to September 27, 2014. Prospective cohort studies investigated FVs intake, and the risk of BC with ≥3 categories of exposure was included. A dose-response meta-analysis was carried out to evaluate the association between FVs intake and risk of BC. Fourteen cohorts with 17 studies including 9447 cases were identified. No evidence of nonlinear association was examined between FVs intake and risk of BC. The summarized relevant risk (RR) of every 0.2 serving increment a day was 1.00 (95%CI: 0.99, 1.00; P = 0.17; I(2) = 41.7%; n = 14) for total fruits; 0.99 (95%CI: 0.96, 1.01; P = 0.28; I(2) = 37.0%; n = 13) for total vegetables; and 0.99 (95%CI: 0.97, 1.01; P = 0.24; I(2) = 57.5%; n = 8) for both FVs. In further analysis, we observed inverse association between every 0.2 serving increment of green leafy vegetables intake a day and risk of BC (RR = 0.98, 95%CI: 0.96, 0.99; I(2) = 0.0%; P < 0.01; Power = 0.76; n = 6), but neither for cruciferous vegetables (RR = 0.97, 95%CI: 0.93, 1.01; P = 0.19; I(2) = 55.8%; n = 8) nor for citrus (RR = 1.00, 95%CI: 1.00, 1.00; P = 0.83; I(2) = 0.0%; n = 7). Subgroup analysis showed consistent results. Little evidence supports a beneficial effect for total fruits, vegetables, both FVs, and citrus intake against bladder cancer. Green leafy vegetables may help prevent bladder cancer.
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spelling pubmed-46030652015-10-27 Fruits and Vegetables Intake and Risk of Bladder Cancer: A PRISMA-Compliant Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies Xu, Chang Zeng, Xian-Tao Liu, Tong-Zu Zhang, Chao Yang, Zhong-Hua Li, Sheng Chen, Xiao-Yan Medicine (Baltimore) 7300 Clinical practice recommends eating ≥2.5 cups of fruits and vegetables (FVs) each day for cancer prevention, in which the evidence from epidemiological studies for the association between FVs intake and bladder cancer (BC) prevention is inconsistent. We searched the PubMed, Embase, and Willy online Library for relevant studies published up to September 27, 2014. Prospective cohort studies investigated FVs intake, and the risk of BC with ≥3 categories of exposure was included. A dose-response meta-analysis was carried out to evaluate the association between FVs intake and risk of BC. Fourteen cohorts with 17 studies including 9447 cases were identified. No evidence of nonlinear association was examined between FVs intake and risk of BC. The summarized relevant risk (RR) of every 0.2 serving increment a day was 1.00 (95%CI: 0.99, 1.00; P = 0.17; I(2) = 41.7%; n = 14) for total fruits; 0.99 (95%CI: 0.96, 1.01; P = 0.28; I(2) = 37.0%; n = 13) for total vegetables; and 0.99 (95%CI: 0.97, 1.01; P = 0.24; I(2) = 57.5%; n = 8) for both FVs. In further analysis, we observed inverse association between every 0.2 serving increment of green leafy vegetables intake a day and risk of BC (RR = 0.98, 95%CI: 0.96, 0.99; I(2) = 0.0%; P < 0.01; Power = 0.76; n = 6), but neither for cruciferous vegetables (RR = 0.97, 95%CI: 0.93, 1.01; P = 0.19; I(2) = 55.8%; n = 8) nor for citrus (RR = 1.00, 95%CI: 1.00, 1.00; P = 0.83; I(2) = 0.0%; n = 7). Subgroup analysis showed consistent results. Little evidence supports a beneficial effect for total fruits, vegetables, both FVs, and citrus intake against bladder cancer. Green leafy vegetables may help prevent bladder cancer. Wolters Kluwer Health 2015-05-01 /pmc/articles/PMC4603065/ /pubmed/25929912 http://dx.doi.org/10.1097/MD.0000000000000759 Text en Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0, where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/4.0
spellingShingle 7300
Xu, Chang
Zeng, Xian-Tao
Liu, Tong-Zu
Zhang, Chao
Yang, Zhong-Hua
Li, Sheng
Chen, Xiao-Yan
Fruits and Vegetables Intake and Risk of Bladder Cancer: A PRISMA-Compliant Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies
title Fruits and Vegetables Intake and Risk of Bladder Cancer: A PRISMA-Compliant Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies
title_full Fruits and Vegetables Intake and Risk of Bladder Cancer: A PRISMA-Compliant Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies
title_fullStr Fruits and Vegetables Intake and Risk of Bladder Cancer: A PRISMA-Compliant Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies
title_full_unstemmed Fruits and Vegetables Intake and Risk of Bladder Cancer: A PRISMA-Compliant Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies
title_short Fruits and Vegetables Intake and Risk of Bladder Cancer: A PRISMA-Compliant Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies
title_sort fruits and vegetables intake and risk of bladder cancer: a prisma-compliant systematic review and dose-response meta-analysis of prospective cohort studies
topic 7300
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603065/
https://www.ncbi.nlm.nih.gov/pubmed/25929912
http://dx.doi.org/10.1097/MD.0000000000000759
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