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Characterization and optimization of the haemozoin-like crystal (HLC) assay to determine Hz inhibiting effects of anti-malarial compounds

BACKGROUND: The haem-haemozoin biocrystallization pathway is an attractive target where several efficacious and safe anti-malarial drugs act. Consequently, in vitro haemozoin (Hz) inhibition assays have been developed to identify novel compounds. However, results may differ between assays and often...

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Detalles Bibliográficos
Autores principales:	Tempera, Carolina, Franco, Ricardo, Caro, Carlos, André, Vânia, Eaton, Peter, Burke, Peter, Hänscheid, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Methodology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603294/ https://www.ncbi.nlm.nih.gov/pubmed/26458401 http://dx.doi.org/10.1186/s12936-015-0913-y

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