Dimethyl fumarate inhibits integrin α4 expression in multiple sclerosis models

Dimethyl fumarate is an orally bioavailable compound for the treatment of multiple sclerosis and psoriasis. A mechanism involving nuclear factor erythroid 2-like 2 activation has been proposed to account for its efficacy in multiple sclerosis. Here, we report that dimethyl fumarate inhibits expressi...

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Detalles Bibliográficos
Autores principales: Kihara, Yasuyuki, Groves, Aran, Rivera, Richard R, Chun, Jerold
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Brief Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603381/
https://www.ncbi.nlm.nih.gov/pubmed/26478898
http://dx.doi.org/10.1002/acn3.251
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author Kihara, Yasuyuki
Groves, Aran
Rivera, Richard R
Chun, Jerold
author_facet Kihara, Yasuyuki
Groves, Aran
Rivera, Richard R
Chun, Jerold
author_sort Kihara, Yasuyuki
collection PubMed
description Dimethyl fumarate is an orally bioavailable compound for the treatment of multiple sclerosis and psoriasis. A mechanism involving nuclear factor erythroid 2-like 2 activation has been proposed to account for its efficacy in multiple sclerosis. Here, we report that dimethyl fumarate inhibits expression of integrin α4 on circulating lymphocytes in experimental autoimmune encephalomyelitis mice and also on activated human Jurkat T cells in a manner distinct from nuclear factor erythroid 2-like 2 activation. Our results offer an alternative mechanism for the efficacy of dimethyl fumarate in multiple sclerosis.
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spelling pubmed-46033812015-10-16 Dimethyl fumarate inhibits integrin α4 expression in multiple sclerosis models Kihara, Yasuyuki Groves, Aran Rivera, Richard R Chun, Jerold Ann Clin Transl Neurol Brief Communications Dimethyl fumarate is an orally bioavailable compound for the treatment of multiple sclerosis and psoriasis. A mechanism involving nuclear factor erythroid 2-like 2 activation has been proposed to account for its efficacy in multiple sclerosis. Here, we report that dimethyl fumarate inhibits expression of integrin α4 on circulating lymphocytes in experimental autoimmune encephalomyelitis mice and also on activated human Jurkat T cells in a manner distinct from nuclear factor erythroid 2-like 2 activation. Our results offer an alternative mechanism for the efficacy of dimethyl fumarate in multiple sclerosis. John Wiley & Sons, Ltd 2015-10 2015-09-11 /pmc/articles/PMC4603381/ /pubmed/26478898 http://dx.doi.org/10.1002/acn3.251 Text en © 2015 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Brief Communications
Kihara, Yasuyuki
Groves, Aran
Rivera, Richard R
Chun, Jerold
Dimethyl fumarate inhibits integrin α4 expression in multiple sclerosis models
title Dimethyl fumarate inhibits integrin α4 expression in multiple sclerosis models
title_full Dimethyl fumarate inhibits integrin α4 expression in multiple sclerosis models
title_fullStr Dimethyl fumarate inhibits integrin α4 expression in multiple sclerosis models
title_full_unstemmed Dimethyl fumarate inhibits integrin α4 expression in multiple sclerosis models
title_short Dimethyl fumarate inhibits integrin α4 expression in multiple sclerosis models
title_sort dimethyl fumarate inhibits integrin α4 expression in multiple sclerosis models
topic Brief Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603381/
https://www.ncbi.nlm.nih.gov/pubmed/26478898
http://dx.doi.org/10.1002/acn3.251
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AT chunjerold dimethylfumarateinhibitsintegrina4expressioninmultiplesclerosismodels

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