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FXYD5 is a Marker for Poor Prognosis and a Potential Driver for Metastasis in Ovarian Carcinomas

Ovarian cancer (OC) is a leading cause of cancer mortality, but aside from a few well-studied mutations, very little is known about its underlying causes. As such, we performed survival analysis on ovarian copy number amplifications and gene expression datasets presented by The Cancer Genome Atlas i...

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Detalles Bibliográficos
Autores principales: Raman, Pichai, Purwin, Timothy, Pestell, Richard, Tozeren, Aydin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Libertas Academica 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603440/
https://www.ncbi.nlm.nih.gov/pubmed/26494976
http://dx.doi.org/10.4137/CIN.S30565
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author Raman, Pichai
Purwin, Timothy
Pestell, Richard
Tozeren, Aydin
author_facet Raman, Pichai
Purwin, Timothy
Pestell, Richard
Tozeren, Aydin
author_sort Raman, Pichai
collection PubMed
description Ovarian cancer (OC) is a leading cause of cancer mortality, but aside from a few well-studied mutations, very little is known about its underlying causes. As such, we performed survival analysis on ovarian copy number amplifications and gene expression datasets presented by The Cancer Genome Atlas in order to identify potential drivers and markers of aggressive OC. Additionally, two independent datasets from the Gene Expression Omnibus web platform were used to validate the identified markers. Based on our analysis, we identified FXYD5, a glycoprotein known to reduce cell adhesion, as a potential driver of metastasis and a significant predictor of mortality in OC. As a marker of poor outcome, the protein has effective antibodies against it for use in tissue arrays. FXYD5 bridges together a wide variety of cancers, including ovarian, breast cancer stage II, thyroid, colorectal, pancreatic, and head and neck cancers for metastasis studies.
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spelling pubmed-46034402015-10-22 FXYD5 is a Marker for Poor Prognosis and a Potential Driver for Metastasis in Ovarian Carcinomas Raman, Pichai Purwin, Timothy Pestell, Richard Tozeren, Aydin Cancer Inform Short Report Ovarian cancer (OC) is a leading cause of cancer mortality, but aside from a few well-studied mutations, very little is known about its underlying causes. As such, we performed survival analysis on ovarian copy number amplifications and gene expression datasets presented by The Cancer Genome Atlas in order to identify potential drivers and markers of aggressive OC. Additionally, two independent datasets from the Gene Expression Omnibus web platform were used to validate the identified markers. Based on our analysis, we identified FXYD5, a glycoprotein known to reduce cell adhesion, as a potential driver of metastasis and a significant predictor of mortality in OC. As a marker of poor outcome, the protein has effective antibodies against it for use in tissue arrays. FXYD5 bridges together a wide variety of cancers, including ovarian, breast cancer stage II, thyroid, colorectal, pancreatic, and head and neck cancers for metastasis studies. Libertas Academica 2015-10-12 /pmc/articles/PMC4603440/ /pubmed/26494976 http://dx.doi.org/10.4137/CIN.S30565 Text en © 2015 the author(s), publisher and licensee Libertas Academica Ltd. This is an open-access article distributed under the terms of the Creative Commons CC-BY-NC 3.0 License.
spellingShingle Short Report
Raman, Pichai
Purwin, Timothy
Pestell, Richard
Tozeren, Aydin
FXYD5 is a Marker for Poor Prognosis and a Potential Driver for Metastasis in Ovarian Carcinomas
title FXYD5 is a Marker for Poor Prognosis and a Potential Driver for Metastasis in Ovarian Carcinomas
title_full FXYD5 is a Marker for Poor Prognosis and a Potential Driver for Metastasis in Ovarian Carcinomas
title_fullStr FXYD5 is a Marker for Poor Prognosis and a Potential Driver for Metastasis in Ovarian Carcinomas
title_full_unstemmed FXYD5 is a Marker for Poor Prognosis and a Potential Driver for Metastasis in Ovarian Carcinomas
title_short FXYD5 is a Marker for Poor Prognosis and a Potential Driver for Metastasis in Ovarian Carcinomas
title_sort fxyd5 is a marker for poor prognosis and a potential driver for metastasis in ovarian carcinomas
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603440/
https://www.ncbi.nlm.nih.gov/pubmed/26494976
http://dx.doi.org/10.4137/CIN.S30565
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