Csf2 and Ptgs2 Epigenetic Dysregulation in Diabetes-prone Bicongenic B6.NODC11bxC1tb Mice

In Type 1 diabetic (T1D) human monocytes, STAT5 aberrantly binds to epigenetic regulatory sites of two proinflammatory genes, CSF2 (encoding granulocyte–macrophage colony-stimulating factor) and PTGS2 (encoding prostaglandin synthase 2/cyclooxygenase 2). Bicongenic B6.NOD C11bxC1tb mice re-create th...

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Detalles Bibliográficos
Autores principales: Garrigan, Erin, Belkin, Nicole S., Seydel, Federica, Han, Zhao, Carter, Jamal, McDuffie, Marcia, Morel, Laurence, Peck, Ammon B., Clare-Salzler, Michael J., Atkinson, Mark, Wasserfall, Clive, Davoodi-Semiromi, Abdoreza, Shi, Jing-da, Haskell-Luevano, Carrie, Yang, Li-Jun, Alexander, John J., Cdebaca, Autumn, Piliant, Teresa, Riggs, Corin, Amick, Matthew, Litherland, Sally A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Libertas Academica 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603573/
https://www.ncbi.nlm.nih.gov/pubmed/26512207
http://dx.doi.org/10.4137/GEG.S29696

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