Targeted Mutation of Nuclear Bone Morphogenetic Protein 2 Impairs Secondary Immune Response in a Mouse Model

We recently identified a nuclear variant of the BMP2 growth factor, called nBMP2. In an effort to understand the function of this variant protein, we generated a mouse line in which BMP2 is expressed and functions normally, but nBMP2 is excluded from the nucleus. This novel mutation allows the study...

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Detalles Bibliográficos
Autores principales: Olsen, Daniel S., Goar, Wesley A., Nichols, Brandt A., Bailey, K. Tyson, Christensen, S. Loyd, Merriam, Kayla R., Reynolds, Paul R., Wilson, Eric, Weber, K. Scott, Bridgewater, Laura C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603606/
https://www.ncbi.nlm.nih.gov/pubmed/26491697
http://dx.doi.org/10.1155/2015/975789

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