Enhancement of Cetuximab-Induced Radiosensitization by JAK-1 Inhibition

BACKGROUND: It is known that cetuximab (an epidermal growth factor receptor [EGFr] inhibitor) is a radiosensitizer. Also, cetuximab is known to only partially inhibit the signal transducer and activator of transcription – 3 (STAT-3); a mediator of protection from apoptosis. Studies were performed to...

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Detalles Bibliográficos
Autores principales: Bonner, James A., Trummell, Hoa Q., Bonner, Andrew B., Willey, Christopher D., Bredel, Markus, Yang, Eddy S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603644/
https://www.ncbi.nlm.nih.gov/pubmed/26458879
http://dx.doi.org/10.1186/s12885-015-1679-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603644/
https://www.ncbi.nlm.nih.gov/pubmed/26458879
http://dx.doi.org/10.1186/s12885-015-1679-x

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