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Varied Probability of Staying Collapsed/Extended at the Conformational Equilibrium of Monomeric Aβ(40) and Aβ(42)

In present study, we set out to investigate the conformation dynamics of Aβ(40) and Aβ(42) through exploring the impact of intra-molecular interactions on conformation dynamics using equilibrium molecular dynamics simulations. Our 40 microsecond-scale simulations reveal heterogeneous conformation en...

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Detalles Bibliográficos
Autores principales: Song, Wanling, Wang, Yuanyuan, Colletier, Jacques-Philippe, Yang, Huaiyu, Xu, Yechun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603783/
https://www.ncbi.nlm.nih.gov/pubmed/26046578
http://dx.doi.org/10.1038/srep11024