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Atypical protein kinase C induces cell transformation by disrupting Hippo/Yap signaling

Epithelial cells are major sites of malignant transformation. Atypical protein kinase C (aPKC) isoforms are overexpressed and activated in many cancer types. Using normal, highly polarized epithelial cells (MDCK and NMuMG), we report that aPKC gain of function overcomes contact inhibited growth and...

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Detalles Bibliográficos
Autores principales:	Archibald, Andrew, Al-Masri, Maia, Liew-Spilger, Alyson, McCaffrey, Luke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2015
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603929/ https://www.ncbi.nlm.nih.gov/pubmed/26269582 http://dx.doi.org/10.1091/mbc.E15-05-0265

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