Risk of Bias in Reports of In Vivo Research: A Focus for Improvement

The reliability of experimental findings depends on the rigour of experimental design. Here we show limited reporting of measures to reduce the risk of bias in a random sample of life sciences publications, significantly lower reporting of randomisation in work published in journals of high impact,...

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Detalles Bibliográficos
Autores principales: Macleod, Malcolm R., Lawson McLean, Aaron, Kyriakopoulou, Aikaterini, Serghiou, Stylianos, de Wilde, Arno, Sherratt, Nicki, Hirst, Theo, Hemblade, Rachel, Bahor, Zsanett, Nunes-Fonseca, Cristina, Potluru, Aparna, Thomson, Andrew, Baginskitae, Julija, Egan, Kieren, Vesterinen, Hanna, Currie, Gillian L., Churilov, Leonid, Howells, David W., Sena, Emily S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603955/
https://www.ncbi.nlm.nih.gov/pubmed/26460723
http://dx.doi.org/10.1371/journal.pbio.1002273
Descripción
Sumario:The reliability of experimental findings depends on the rigour of experimental design. Here we show limited reporting of measures to reduce the risk of bias in a random sample of life sciences publications, significantly lower reporting of randomisation in work published in journals of high impact, and very limited reporting of measures to reduce the risk of bias in publications from leading United Kingdom institutions. Ascertainment of differences between institutions might serve both as a measure of research quality and as a tool for institutional efforts to improve research quality.

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