Risk of Bias in Reports of In Vivo Research: A Focus for Improvement

The reliability of experimental findings depends on the rigour of experimental design. Here we show limited reporting of measures to reduce the risk of bias in a random sample of life sciences publications, significantly lower reporting of randomisation in work published in journals of high impact,...

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Autores principales: Macleod, Malcolm R., Lawson McLean, Aaron, Kyriakopoulou, Aikaterini, Serghiou, Stylianos, de Wilde, Arno, Sherratt, Nicki, Hirst, Theo, Hemblade, Rachel, Bahor, Zsanett, Nunes-Fonseca, Cristina, Potluru, Aparna, Thomson, Andrew, Baginskitae, Julija, Egan, Kieren, Vesterinen, Hanna, Currie, Gillian L., Churilov, Leonid, Howells, David W., Sena, Emily S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603955/
https://www.ncbi.nlm.nih.gov/pubmed/26460723
http://dx.doi.org/10.1371/journal.pbio.1002273
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author Macleod, Malcolm R.
Lawson McLean, Aaron
Kyriakopoulou, Aikaterini
Serghiou, Stylianos
de Wilde, Arno
Sherratt, Nicki
Hirst, Theo
Hemblade, Rachel
Bahor, Zsanett
Nunes-Fonseca, Cristina
Potluru, Aparna
Thomson, Andrew
Baginskitae, Julija
Egan, Kieren
Vesterinen, Hanna
Currie, Gillian L.
Churilov, Leonid
Howells, David W.
Sena, Emily S.
author_facet Macleod, Malcolm R.
Lawson McLean, Aaron
Kyriakopoulou, Aikaterini
Serghiou, Stylianos
de Wilde, Arno
Sherratt, Nicki
Hirst, Theo
Hemblade, Rachel
Bahor, Zsanett
Nunes-Fonseca, Cristina
Potluru, Aparna
Thomson, Andrew
Baginskitae, Julija
Egan, Kieren
Vesterinen, Hanna
Currie, Gillian L.
Churilov, Leonid
Howells, David W.
Sena, Emily S.
author_sort Macleod, Malcolm R.
collection PubMed
description The reliability of experimental findings depends on the rigour of experimental design. Here we show limited reporting of measures to reduce the risk of bias in a random sample of life sciences publications, significantly lower reporting of randomisation in work published in journals of high impact, and very limited reporting of measures to reduce the risk of bias in publications from leading United Kingdom institutions. Ascertainment of differences between institutions might serve both as a measure of research quality and as a tool for institutional efforts to improve research quality.
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spelling pubmed-46039552015-10-20 Risk of Bias in Reports of In Vivo Research: A Focus for Improvement Macleod, Malcolm R. Lawson McLean, Aaron Kyriakopoulou, Aikaterini Serghiou, Stylianos de Wilde, Arno Sherratt, Nicki Hirst, Theo Hemblade, Rachel Bahor, Zsanett Nunes-Fonseca, Cristina Potluru, Aparna Thomson, Andrew Baginskitae, Julija Egan, Kieren Vesterinen, Hanna Currie, Gillian L. Churilov, Leonid Howells, David W. Sena, Emily S. PLoS Biol Perspective The reliability of experimental findings depends on the rigour of experimental design. Here we show limited reporting of measures to reduce the risk of bias in a random sample of life sciences publications, significantly lower reporting of randomisation in work published in journals of high impact, and very limited reporting of measures to reduce the risk of bias in publications from leading United Kingdom institutions. Ascertainment of differences between institutions might serve both as a measure of research quality and as a tool for institutional efforts to improve research quality. Public Library of Science 2015-10-13 /pmc/articles/PMC4603955/ /pubmed/26460723 http://dx.doi.org/10.1371/journal.pbio.1002273 Text en © 2015 Macleod et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Perspective
Macleod, Malcolm R.
Lawson McLean, Aaron
Kyriakopoulou, Aikaterini
Serghiou, Stylianos
de Wilde, Arno
Sherratt, Nicki
Hirst, Theo
Hemblade, Rachel
Bahor, Zsanett
Nunes-Fonseca, Cristina
Potluru, Aparna
Thomson, Andrew
Baginskitae, Julija
Egan, Kieren
Vesterinen, Hanna
Currie, Gillian L.
Churilov, Leonid
Howells, David W.
Sena, Emily S.
Risk of Bias in Reports of In Vivo Research: A Focus for Improvement
title Risk of Bias in Reports of In Vivo Research: A Focus for Improvement
title_full Risk of Bias in Reports of In Vivo Research: A Focus for Improvement
title_fullStr Risk of Bias in Reports of In Vivo Research: A Focus for Improvement
title_full_unstemmed Risk of Bias in Reports of In Vivo Research: A Focus for Improvement
title_short Risk of Bias in Reports of In Vivo Research: A Focus for Improvement
title_sort risk of bias in reports of in vivo research: a focus for improvement
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603955/
https://www.ncbi.nlm.nih.gov/pubmed/26460723
http://dx.doi.org/10.1371/journal.pbio.1002273
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