Increased FGF23 serum level is associated with unstable carotid plaque in type 2 diabetic subjects with internal carotid stenosis

BACKGROUND: The object of this study was to investigate the potential role of FGF23 on plaque stability in type 2 diabetic patients with internal carotid artery stenosis. METHODS: In this retrospective observational study, we analyzed FGF23 serum level in 361 type 2 diabetic patients with internal c...

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Autores principales: Biscetti, Federico, Straface, Giuseppe, Porreca, Carlo Filippo, Bertoletti, Giovanni, Vincenzoni, Claudio, Snider, Francesco, Stigliano, Egidio, Arena, Vincenzo, Angelini, Flavia, Pecorini, Giovanni, Bianchi, Antonio, Landolfi, Raffaele, Flex, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603970/
https://www.ncbi.nlm.nih.gov/pubmed/26459301
http://dx.doi.org/10.1186/s12933-015-0301-5
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author Biscetti, Federico
Straface, Giuseppe
Porreca, Carlo Filippo
Bertoletti, Giovanni
Vincenzoni, Claudio
Snider, Francesco
Stigliano, Egidio
Arena, Vincenzo
Angelini, Flavia
Pecorini, Giovanni
Bianchi, Antonio
Landolfi, Raffaele
Flex, Andrea
author_facet Biscetti, Federico
Straface, Giuseppe
Porreca, Carlo Filippo
Bertoletti, Giovanni
Vincenzoni, Claudio
Snider, Francesco
Stigliano, Egidio
Arena, Vincenzo
Angelini, Flavia
Pecorini, Giovanni
Bianchi, Antonio
Landolfi, Raffaele
Flex, Andrea
author_sort Biscetti, Federico
collection PubMed
description BACKGROUND: The object of this study was to investigate the potential role of FGF23 on plaque stability in type 2 diabetic patients with internal carotid artery stenosis. METHODS: In this retrospective observational study, we analyzed FGF23 serum level in 361 type 2 diabetic patients with internal carotid artery stenosis undergoing carotid endarterectomy and in 598 diabetic controls without carotid atherosclerosis. RESULTS: We found that FGF23 median serum levels was significantly higher in patients than in diabetic controls [67.7 (59.5–77.8) pg/mL and 43.89 (37.5–50.4), P < 0.001] and was significantly and independently associated with unstable plaque in patients with internal carotid artery stenosis [OR, 5,71 (95 % CI, 2.09–15.29]. CONCLUSIONS: We have found, for the first time, that FGF23 could be associated with unstable plaque in type 2 diabetic patients with internal carotid artery stenosis.
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spelling pubmed-46039702015-10-14 Increased FGF23 serum level is associated with unstable carotid plaque in type 2 diabetic subjects with internal carotid stenosis Biscetti, Federico Straface, Giuseppe Porreca, Carlo Filippo Bertoletti, Giovanni Vincenzoni, Claudio Snider, Francesco Stigliano, Egidio Arena, Vincenzo Angelini, Flavia Pecorini, Giovanni Bianchi, Antonio Landolfi, Raffaele Flex, Andrea Cardiovasc Diabetol Original Investigation BACKGROUND: The object of this study was to investigate the potential role of FGF23 on plaque stability in type 2 diabetic patients with internal carotid artery stenosis. METHODS: In this retrospective observational study, we analyzed FGF23 serum level in 361 type 2 diabetic patients with internal carotid artery stenosis undergoing carotid endarterectomy and in 598 diabetic controls without carotid atherosclerosis. RESULTS: We found that FGF23 median serum levels was significantly higher in patients than in diabetic controls [67.7 (59.5–77.8) pg/mL and 43.89 (37.5–50.4), P < 0.001] and was significantly and independently associated with unstable plaque in patients with internal carotid artery stenosis [OR, 5,71 (95 % CI, 2.09–15.29]. CONCLUSIONS: We have found, for the first time, that FGF23 could be associated with unstable plaque in type 2 diabetic patients with internal carotid artery stenosis. BioMed Central 2015-10-12 /pmc/articles/PMC4603970/ /pubmed/26459301 http://dx.doi.org/10.1186/s12933-015-0301-5 Text en © Biscetti et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Original Investigation
Biscetti, Federico
Straface, Giuseppe
Porreca, Carlo Filippo
Bertoletti, Giovanni
Vincenzoni, Claudio
Snider, Francesco
Stigliano, Egidio
Arena, Vincenzo
Angelini, Flavia
Pecorini, Giovanni
Bianchi, Antonio
Landolfi, Raffaele
Flex, Andrea
Increased FGF23 serum level is associated with unstable carotid plaque in type 2 diabetic subjects with internal carotid stenosis
title Increased FGF23 serum level is associated with unstable carotid plaque in type 2 diabetic subjects with internal carotid stenosis
title_full Increased FGF23 serum level is associated with unstable carotid plaque in type 2 diabetic subjects with internal carotid stenosis
title_fullStr Increased FGF23 serum level is associated with unstable carotid plaque in type 2 diabetic subjects with internal carotid stenosis
title_full_unstemmed Increased FGF23 serum level is associated with unstable carotid plaque in type 2 diabetic subjects with internal carotid stenosis
title_short Increased FGF23 serum level is associated with unstable carotid plaque in type 2 diabetic subjects with internal carotid stenosis
title_sort increased fgf23 serum level is associated with unstable carotid plaque in type 2 diabetic subjects with internal carotid stenosis
topic Original Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603970/
https://www.ncbi.nlm.nih.gov/pubmed/26459301
http://dx.doi.org/10.1186/s12933-015-0301-5
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