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Age-Related Changes in Corneal Deformation Dynamics Utilizing Scheimpflug Imaging

PURPOSE: To study age-related changes in corneal deformation response to air-puff applanation tonometry. METHODS: Fifty healthy subjects were recruited for a prospective study and divided into two equal age groups (≤ 28 and ≥ 50 years old). Up to three measurements by a corneal deformation analyser...

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Autores principales: Rogowska, Marta E., Iskander, D. Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604157/
https://www.ncbi.nlm.nih.gov/pubmed/26460972
http://dx.doi.org/10.1371/journal.pone.0140093
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author Rogowska, Marta E.
Iskander, D. Robert
author_facet Rogowska, Marta E.
Iskander, D. Robert
author_sort Rogowska, Marta E.
collection PubMed
description PURPOSE: To study age-related changes in corneal deformation response to air-puff applanation tonometry. METHODS: Fifty healthy subjects were recruited for a prospective study and divided into two equal age groups (≤ 28 and ≥ 50 years old). Up to three measurements by a corneal deformation analyser based on the Scheimpflug principle were performed on the left eye of each subject. Raw Scheimpflug images were used to extract changes in anterior and posterior corneal profiles, which were further modelled by an orthogonal series of Chebyshev polynomial functions. Time series of the polynomial coefficients of even order exhibited a dynamic behavior in which three distinct stages were recognized. A bilinear function was used to model the first and the third stage of corneal dynamics. Slope parameters of the bilinear fit were then tested between the two age groups using Wilcoxon rank sum test and two-way non-parametric ANOVA (Friedman) test. RESULTS: Statistically significant changes (Wilcoxon test, P<0.05) between the age groups were observed in the phase of the second applanation dynamics for the posterior corneal profile. In a two-way comparison, in which the corneal profile was used as a dependent variable, statistically significant changes (ANOVA/Friedman test, P = 0.017) between the groups were also observed for that phase. CONCLUSION: Corneal biomechanics depend on age. The changes in corneal deformation dynamics, which correspond to mostly free return of the cornea to its original shape after the air pulse, indicate that the age related differences in corneal biomechanics are subtle but observable with high speed imaging.
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spelling pubmed-46041572015-10-20 Age-Related Changes in Corneal Deformation Dynamics Utilizing Scheimpflug Imaging Rogowska, Marta E. Iskander, D. Robert PLoS One Research Article PURPOSE: To study age-related changes in corneal deformation response to air-puff applanation tonometry. METHODS: Fifty healthy subjects were recruited for a prospective study and divided into two equal age groups (≤ 28 and ≥ 50 years old). Up to three measurements by a corneal deformation analyser based on the Scheimpflug principle were performed on the left eye of each subject. Raw Scheimpflug images were used to extract changes in anterior and posterior corneal profiles, which were further modelled by an orthogonal series of Chebyshev polynomial functions. Time series of the polynomial coefficients of even order exhibited a dynamic behavior in which three distinct stages were recognized. A bilinear function was used to model the first and the third stage of corneal dynamics. Slope parameters of the bilinear fit were then tested between the two age groups using Wilcoxon rank sum test and two-way non-parametric ANOVA (Friedman) test. RESULTS: Statistically significant changes (Wilcoxon test, P<0.05) between the age groups were observed in the phase of the second applanation dynamics for the posterior corneal profile. In a two-way comparison, in which the corneal profile was used as a dependent variable, statistically significant changes (ANOVA/Friedman test, P = 0.017) between the groups were also observed for that phase. CONCLUSION: Corneal biomechanics depend on age. The changes in corneal deformation dynamics, which correspond to mostly free return of the cornea to its original shape after the air pulse, indicate that the age related differences in corneal biomechanics are subtle but observable with high speed imaging. Public Library of Science 2015-10-13 /pmc/articles/PMC4604157/ /pubmed/26460972 http://dx.doi.org/10.1371/journal.pone.0140093 Text en © 2015 Rogowska, Iskander http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Rogowska, Marta E.
Iskander, D. Robert
Age-Related Changes in Corneal Deformation Dynamics Utilizing Scheimpflug Imaging
title Age-Related Changes in Corneal Deformation Dynamics Utilizing Scheimpflug Imaging
title_full Age-Related Changes in Corneal Deformation Dynamics Utilizing Scheimpflug Imaging
title_fullStr Age-Related Changes in Corneal Deformation Dynamics Utilizing Scheimpflug Imaging
title_full_unstemmed Age-Related Changes in Corneal Deformation Dynamics Utilizing Scheimpflug Imaging
title_short Age-Related Changes in Corneal Deformation Dynamics Utilizing Scheimpflug Imaging
title_sort age-related changes in corneal deformation dynamics utilizing scheimpflug imaging
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604157/
https://www.ncbi.nlm.nih.gov/pubmed/26460972
http://dx.doi.org/10.1371/journal.pone.0140093
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