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Pallial patterning and the origin of the isocortex
Together with a complex variety of behavioral, physiological, morphological, and neurobiological innovations, mammals are characterized by the development of an extensive isocortex (also called neocortex) that is both laminated and radially organized, as opposed to the brain of birds and reptiles. I...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604247/ https://www.ncbi.nlm.nih.gov/pubmed/26512233 http://dx.doi.org/10.3389/fnins.2015.00377 |
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author | Montiel, Juan F. Aboitiz, Francisco |
author_facet | Montiel, Juan F. Aboitiz, Francisco |
author_sort | Montiel, Juan F. |
collection | PubMed |
description | Together with a complex variety of behavioral, physiological, morphological, and neurobiological innovations, mammals are characterized by the development of an extensive isocortex (also called neocortex) that is both laminated and radially organized, as opposed to the brain of birds and reptiles. In this article, we will advance a developmental hypothesis in which the mechanisms of evolutionary brain growth remain partly conserved across amniotes (mammals, reptiles and birds), all based on Pax6 signaling or related morphogens. Despite this conservatism, only in mammals there is an additional upregulation of dorsal and anterior signaling centers (the cortical hem and the anterior forebrain, respectively) that promoted a laminar and a columnar structure into the neocortex. It is possible that independently, some birds also developed an upregulated dorsal pallium. |
format | Online Article Text |
id | pubmed-4604247 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-46042472015-10-28 Pallial patterning and the origin of the isocortex Montiel, Juan F. Aboitiz, Francisco Front Neurosci Psychology Together with a complex variety of behavioral, physiological, morphological, and neurobiological innovations, mammals are characterized by the development of an extensive isocortex (also called neocortex) that is both laminated and radially organized, as opposed to the brain of birds and reptiles. In this article, we will advance a developmental hypothesis in which the mechanisms of evolutionary brain growth remain partly conserved across amniotes (mammals, reptiles and birds), all based on Pax6 signaling or related morphogens. Despite this conservatism, only in mammals there is an additional upregulation of dorsal and anterior signaling centers (the cortical hem and the anterior forebrain, respectively) that promoted a laminar and a columnar structure into the neocortex. It is possible that independently, some birds also developed an upregulated dorsal pallium. Frontiers Media S.A. 2015-10-14 /pmc/articles/PMC4604247/ /pubmed/26512233 http://dx.doi.org/10.3389/fnins.2015.00377 Text en Copyright © 2015 Montiel and Aboitiz. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Psychology Montiel, Juan F. Aboitiz, Francisco Pallial patterning and the origin of the isocortex |
title | Pallial patterning and the origin of the isocortex |
title_full | Pallial patterning and the origin of the isocortex |
title_fullStr | Pallial patterning and the origin of the isocortex |
title_full_unstemmed | Pallial patterning and the origin of the isocortex |
title_short | Pallial patterning and the origin of the isocortex |
title_sort | pallial patterning and the origin of the isocortex |
topic | Psychology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604247/ https://www.ncbi.nlm.nih.gov/pubmed/26512233 http://dx.doi.org/10.3389/fnins.2015.00377 |
work_keys_str_mv | AT montieljuanf pallialpatterningandtheoriginoftheisocortex AT aboitizfrancisco pallialpatterningandtheoriginoftheisocortex |