Widespread JNK-dependent alternative splicing induces a positive feedback loop through CELF2-mediated regulation of MKK7 during T-cell activation

Alternative splicing is prevalent among genes encoding signaling molecules; however, the functional consequence of differential isoform expression remains largely unknown. Here we demonstrate that, in response to T-cell activation, the Jun kinase (JNK) kinase MAP kinase kinase 7 (MKK7) is alternativ...

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Detalles Bibliográficos
Autores principales: Martinez, Nicole M., Agosto, Laura, Qiu, Jinsong, Mallory, Michael J., Gazzara, Matthew R., Barash, Yoseph, Fu, Xiang-dong, Lynch, Kristen W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604346/
https://www.ncbi.nlm.nih.gov/pubmed/26443849
http://dx.doi.org/10.1101/gad.267245.115

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