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PRIMA-1(MET) induces death in soft-tissue sarcomas cell independent of p53

BACKGROUND: The aim of this study was to explore the efficacy and define mechanisms of action of PRIMA-1(MET) as a TP53 targeted therapy in soft-tissue sarcoma (STS) cells. METHODS: We investigated effects of PRIMA-1(MET) on apoptosis, cell cycle, and induction of oxidative stress and autophagy in a...

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Detalles Bibliográficos
Autores principales:	Grellety, Thomas, Laroche-Clary, Audrey, Chaire, Vanessa, Lagarde, Pauline, Chibon, Frédéric, Neuville, Agnes, Italiano, Antoine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604610/ https://www.ncbi.nlm.nih.gov/pubmed/26463477 http://dx.doi.org/10.1186/s12885-015-1667-1

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