Multiplicative interaction of functional inflammasome genetic variants in determining the risk of gout

INTRODUCTION: The acute gout flare results from a localised self-limiting innate immune response to monosodium urate (MSU) crystals deposited in joints in hyperuricaemic individuals. Activation of the caspase recruitment domain-containing protein 8 (CARD8) NOD-like receptor pyrin-containing 3 (NLRP3...

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Detalles Bibliográficos
Autores principales: McKinney, Cushla, Stamp, Lisa K., Dalbeth, Nicola, Topless, Ruth K., Day, Richard O., Kannangara, Diluk RW, Williams, Kenneth M., Janssen, Matthijs, Jansen, Timothy L., Joosten, Leo A., Radstake, Timothy R., Riches, Philip L., Tausche, Anne-Kathrin, Lioté, Frederic, So, Alexander, Merriman, Tony R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604627/
https://www.ncbi.nlm.nih.gov/pubmed/26462562
http://dx.doi.org/10.1186/s13075-015-0802-3

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