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Bixa orellana leaf extract suppresses histamine-induced endothelial hyperpermeability via the PLC-NO-cGMP signaling cascade

BACKGROUND: Histamine is established as a potent inflammatory mediator and it is known to increased endothelial permeability by promoting gap formation between endothelial cells. Previous studies have shown that aqueous extract of Bixa orellana leaves (AEBO) exhibits antihistamine activity in vivo,...

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Detalles Bibliográficos
Autores principales:	Yong, Yoke Keong, Chiong, Hoe Siong, Somchit, Muhd Nazrul, Ahmad, Zuraini
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604723/ https://www.ncbi.nlm.nih.gov/pubmed/26468073 http://dx.doi.org/10.1186/s12906-015-0901-3

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