The roles of stem cell memory T cells in hematological malignancies

Adoptive cell therapy (ACT) is rapidly migrating from bench to clinical therapy for hematological malignancies. Recently, a new subtype of memory T cells, stem cell memory T (T(SCM)) cells, was shown to be one of the most favorable subsets for ACT. T(SCM) has high self-renewal capacity and is associ...

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Detalles Bibliográficos
Autores principales: Xu, Ling, Zhang, Yikai, Luo, Gengxin, Li, Yangqiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605076/
https://www.ncbi.nlm.nih.gov/pubmed/26462561
http://dx.doi.org/10.1186/s13045-015-0214-5
Descripción
Sumario:Adoptive cell therapy (ACT) is rapidly migrating from bench to clinical therapy for hematological malignancies. Recently, a new subtype of memory T cells, stem cell memory T (T(SCM)) cells, was shown to be one of the most favorable subsets for ACT. T(SCM) has high self-renewal capacity and is associated with superior T cell engraftment, persistence, and antitumor immunity. In this review, we focused on the characteristics of antigen-specific T(SCM) cells and discussed their potential for immunotherapy targeting hematological malignancies.

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