The roles of stem cell memory T cells in hematological malignancies

Adoptive cell therapy (ACT) is rapidly migrating from bench to clinical therapy for hematological malignancies. Recently, a new subtype of memory T cells, stem cell memory T (T(SCM)) cells, was shown to be one of the most favorable subsets for ACT. T(SCM) has high self-renewal capacity and is associ...

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Detalles Bibliográficos
Autores principales: Xu, Ling, Zhang, Yikai, Luo, Gengxin, Li, Yangqiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605076/
https://www.ncbi.nlm.nih.gov/pubmed/26462561
http://dx.doi.org/10.1186/s13045-015-0214-5
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author Xu, Ling
Zhang, Yikai
Luo, Gengxin
Li, Yangqiu
author_facet Xu, Ling
Zhang, Yikai
Luo, Gengxin
Li, Yangqiu
author_sort Xu, Ling
collection PubMed
description Adoptive cell therapy (ACT) is rapidly migrating from bench to clinical therapy for hematological malignancies. Recently, a new subtype of memory T cells, stem cell memory T (T(SCM)) cells, was shown to be one of the most favorable subsets for ACT. T(SCM) has high self-renewal capacity and is associated with superior T cell engraftment, persistence, and antitumor immunity. In this review, we focused on the characteristics of antigen-specific T(SCM) cells and discussed their potential for immunotherapy targeting hematological malignancies.
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spelling pubmed-46050762015-10-15 The roles of stem cell memory T cells in hematological malignancies Xu, Ling Zhang, Yikai Luo, Gengxin Li, Yangqiu J Hematol Oncol Review Adoptive cell therapy (ACT) is rapidly migrating from bench to clinical therapy for hematological malignancies. Recently, a new subtype of memory T cells, stem cell memory T (T(SCM)) cells, was shown to be one of the most favorable subsets for ACT. T(SCM) has high self-renewal capacity and is associated with superior T cell engraftment, persistence, and antitumor immunity. In this review, we focused on the characteristics of antigen-specific T(SCM) cells and discussed their potential for immunotherapy targeting hematological malignancies. BioMed Central 2015-10-14 /pmc/articles/PMC4605076/ /pubmed/26462561 http://dx.doi.org/10.1186/s13045-015-0214-5 Text en © Xu et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Xu, Ling
Zhang, Yikai
Luo, Gengxin
Li, Yangqiu
The roles of stem cell memory T cells in hematological malignancies
title The roles of stem cell memory T cells in hematological malignancies
title_full The roles of stem cell memory T cells in hematological malignancies
title_fullStr The roles of stem cell memory T cells in hematological malignancies
title_full_unstemmed The roles of stem cell memory T cells in hematological malignancies
title_short The roles of stem cell memory T cells in hematological malignancies
title_sort roles of stem cell memory t cells in hematological malignancies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605076/
https://www.ncbi.nlm.nih.gov/pubmed/26462561
http://dx.doi.org/10.1186/s13045-015-0214-5
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