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Oxaliplatin-Induced Tonic-Clonic Seizures
Oxaliplatin is a common chemotherapy drug used for colon and gastric cancers. Common side effects are peripheral neuropathy, hematological toxicity, and allergic reactions. A rare side effect is seizures which are usually associated with posterior reversible leukoencephalopathy syndrome (PRES). A 50...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605261/ https://www.ncbi.nlm.nih.gov/pubmed/26491586 http://dx.doi.org/10.1155/2015/879217 |
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author | Rahal, Ahmad K. Truong, Phu V. Kallail, K. James |
author_facet | Rahal, Ahmad K. Truong, Phu V. Kallail, K. James |
author_sort | Rahal, Ahmad K. |
collection | PubMed |
description | Oxaliplatin is a common chemotherapy drug used for colon and gastric cancers. Common side effects are peripheral neuropathy, hematological toxicity, and allergic reactions. A rare side effect is seizures which are usually associated with posterior reversible leukoencephalopathy syndrome (PRES). A 50-year-old male patient presented with severe abdominal pain. CT scan of the abdomen showed acute appendicitis. Appendectomy was done and pathology showed mixed adenoneuroendocrine carcinoma. Adjuvant chemotherapy was started with Folinic acid, Fluorouracil, and Oxaliplatin (FOLFOX). During the third cycle of FOLFOX, the patient developed tonic-clonic seizures. Laboratory workup was within normal limits. EEG and MRI of the brain showed no acute abnormality. The patient was rechallenged with FOLFOX but he had tonic-clonic seizures for the second time. His chemotherapy regimen was switched to Folinic acid, Fluorouracil, and Irinotecan (FOLFIRI). After 5 cycles of FOLFIRI, the patient did not develop any seizures, making Oxaliplatin the most likely culprit for his seizures. Oxaliplatin-induced seizures rarely occur in the absence of PRES. One case report has been described in the literature. We present a rare case of tonic-clonic seizures in a patient receiving Oxaliplatin in the absence of PRES. |
format | Online Article Text |
id | pubmed-4605261 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-46052612015-10-21 Oxaliplatin-Induced Tonic-Clonic Seizures Rahal, Ahmad K. Truong, Phu V. Kallail, K. James Case Rep Oncol Med Case Report Oxaliplatin is a common chemotherapy drug used for colon and gastric cancers. Common side effects are peripheral neuropathy, hematological toxicity, and allergic reactions. A rare side effect is seizures which are usually associated with posterior reversible leukoencephalopathy syndrome (PRES). A 50-year-old male patient presented with severe abdominal pain. CT scan of the abdomen showed acute appendicitis. Appendectomy was done and pathology showed mixed adenoneuroendocrine carcinoma. Adjuvant chemotherapy was started with Folinic acid, Fluorouracil, and Oxaliplatin (FOLFOX). During the third cycle of FOLFOX, the patient developed tonic-clonic seizures. Laboratory workup was within normal limits. EEG and MRI of the brain showed no acute abnormality. The patient was rechallenged with FOLFOX but he had tonic-clonic seizures for the second time. His chemotherapy regimen was switched to Folinic acid, Fluorouracil, and Irinotecan (FOLFIRI). After 5 cycles of FOLFIRI, the patient did not develop any seizures, making Oxaliplatin the most likely culprit for his seizures. Oxaliplatin-induced seizures rarely occur in the absence of PRES. One case report has been described in the literature. We present a rare case of tonic-clonic seizures in a patient receiving Oxaliplatin in the absence of PRES. Hindawi Publishing Corporation 2015 2015-09-30 /pmc/articles/PMC4605261/ /pubmed/26491586 http://dx.doi.org/10.1155/2015/879217 Text en Copyright © 2015 Ahmad K. Rahal et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Rahal, Ahmad K. Truong, Phu V. Kallail, K. James Oxaliplatin-Induced Tonic-Clonic Seizures |
title | Oxaliplatin-Induced Tonic-Clonic Seizures |
title_full | Oxaliplatin-Induced Tonic-Clonic Seizures |
title_fullStr | Oxaliplatin-Induced Tonic-Clonic Seizures |
title_full_unstemmed | Oxaliplatin-Induced Tonic-Clonic Seizures |
title_short | Oxaliplatin-Induced Tonic-Clonic Seizures |
title_sort | oxaliplatin-induced tonic-clonic seizures |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605261/ https://www.ncbi.nlm.nih.gov/pubmed/26491586 http://dx.doi.org/10.1155/2015/879217 |
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