RlmCD-mediated U747 methylation promotes efficient G748 methylation by methyltransferase RlmA(II) in 23S rRNA in Streptococcus pneumoniae; interplay between two rRNA methylations responsible for telithromycin susceptibility

Adenine at position 752 in a loop of helix 35 from positions 745 to 752 in domain II of 23S rRNA is involved in binding to the ribosome of telithromycin (TEL), a member of ketolides. Methylation of guanine at position 748 by the intrinsic methyltransferase RlmA(II) enhances binding of telithromycin...

Descripción completa

Detalles Bibliográficos
Autores principales: Shoji, Tatsuma, Takaya, Akiko, Sato, Yoshiharu, Kimura, Satoshi, Suzuki, Tsutomu, Yamamoto, Tomoko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605293/
https://www.ncbi.nlm.nih.gov/pubmed/26365244
http://dx.doi.org/10.1093/nar/gkv609

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605293/
https://www.ncbi.nlm.nih.gov/pubmed/26365244
http://dx.doi.org/10.1093/nar/gkv609

Ejemplares similares