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Structure-function relationships governing activity and stability of a DNA alkylation damage repair thermostable protein

Alkylated DNA-protein alkyltransferases repair alkylated DNA bases, which are among the most common DNA lesions, and are evolutionary conserved, from prokaryotes to higher eukaryotes. The human ortholog, hAGT, is involved in resistance to alkylating chemotherapy drugs. We report here on the alkylate...

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Detalles Bibliográficos
Autores principales:	Perugino, Giuseppe, Miggiano, Riccardo, Serpe, Mario, Vettone, Antonella, Valenti, Anna, Lahiri, Samarpita, Rossi, Franca, Rossi, Mosè, Rizzi, Menico, Ciaramella, Maria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605297/ https://www.ncbi.nlm.nih.gov/pubmed/26227971 http://dx.doi.org/10.1093/nar/gkv774

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