Cargando…
Loss of EZH2 results in precocious mammary gland development and activation of STAT5-dependent genes
Establishment and differentiation of mammary alveoli during pregnancy are controlled by prolactin through the transcription factors STAT5A and STAT5B (STAT5), which also regulate temporal activation of mammary signature genes. This study addressed the question whether the methyltransferase and trans...
Autores principales: | Yoo, Kyung Hyun, Oh, Sumin, Kang, Keunsoo, Hensel, Tim, Robinson, Gertraud W., Hennighausen, Lothar |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605299/ https://www.ncbi.nlm.nih.gov/pubmed/26250110 http://dx.doi.org/10.1093/nar/gkv776 |
Ejemplares similares
-
Sequential activation of genetic programs in mouse mammary epithelium during pregnancy depends on STAT5A/B concentration
por: Yamaji, Daisuke, et al.
Publicado: (2013) -
An autoregulatory enhancer controls mammary-specific STAT5 functions
por: Metser, Gil, et al.
Publicado: (2016) -
Genome-wide analyses reveal the extent of opportunistic STAT5 binding that does not yield transcriptional activation of neighboring genes
por: Zhu, Bing-Mei, et al.
Publicado: (2012) -
Ezh2 promotes clock function and hematopoiesis independent of histone methyltransferase activity in zebrafish
por: Zhong, Yingbin, et al.
Publicado: (2018) -
The phosphatase interactor NIPP1 regulates the occupancy of the histone methyltransferase EZH2 at Polycomb targets
por: Van Dessel, Nele, et al.
Publicado: (2010)