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A conserved Polϵ binding module in Ctf18-RFC is required for S-phase checkpoint activation downstream of Mec1

Defects during chromosome replication in eukaryotes activate a signaling pathway called the S-phase checkpoint, which produces a multifaceted response that preserves genome integrity at stalled DNA replication forks. Work with budding yeast showed that the ‘alternative clamp loader’ known as Ctf18-R...

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Detalles Bibliográficos
Autores principales:	García-Rodríguez, Luis J., De Piccoli, Giacomo, Marchesi, Vanessa, Jones, Richard C., Edmondson, Ricky D., Labib, Karim
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605302/ https://www.ncbi.nlm.nih.gov/pubmed/26250113 http://dx.doi.org/10.1093/nar/gkv799

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