TRAP150 interacts with the RNA-binding domain of PSF and antagonizes splicing of numerous PSF-target genes in T cells

PSF (a.k.a. SFPQ) is a ubiquitously expressed, essential nuclear protein with important roles in DNA damage repair and RNA biogenesis. In stimulated T cells, PSF binds to and suppresses the inclusion of CD45 exon 4 in the final mRNA; however, in resting cells, TRAP150 binds PSF and prevents access t...

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Detalles Bibliográficos
Autores principales: Yarosh, Christopher A., Tapescu, Iulia, Thompson, Matthew G., Qiu, Jinsong, Mallory, Michael J., Fu, Xiang-Dong, Lynch, Kristen W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605305/
https://www.ncbi.nlm.nih.gov/pubmed/26261210
http://dx.doi.org/10.1093/nar/gkv816

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