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Role of a non-canonical surface of Rad6 in ubiquitin conjugating activity

Rad6 is a yeast E2 ubiquitin conjugating enzyme that monoubiquitinates histone H2B in conjunction with the E3, Bre1, but can non-specifically modify histones on its own. We determined the crystal structure of a Rad6∼Ub thioester mimic, which revealed a network of interactions in the crystal in which...

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Detalles Bibliográficos
Autores principales:	Kumar, Pankaj, Magala, Pearl, Geiger-Schuller, Kathryn R., Majumdar, Ananya, Tolman, Joel R., Wolberger, Cynthia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605308/ https://www.ncbi.nlm.nih.gov/pubmed/26286193 http://dx.doi.org/10.1093/nar/gkv845

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