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Structural basis for the Smad5 MH1 domain to recognize different DNA sequences

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Smad proteins are important intracellular mediators of TGF-β signalling, which transmit signals directly from cell surface receptors to the nucleus. The MH1 domain of Smad plays a key role in DNA recognition. Two types of DNA sequence were identified as Smad binding motifs: the Smad binding element...

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Detalles Bibliográficos
Autores principales:	Chai, Nan, Li, Wan-Xin, Wang, Jue, Wang, Zhi-Xin, Yang, Shi-Ming, Wu, Jia-Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605309/ https://www.ncbi.nlm.nih.gov/pubmed/26304548 http://dx.doi.org/10.1093/nar/gkv848

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