Cell type-selective disease-association of genes under high regulatory load

We previously showed that disease-linked metabolic genes are often under combinatorial regulation. Using the genome-wide ChIP-Seq binding profiles for 93 transcription factors in nine different cell lines, we show that genes under high regulatory load are significantly enriched for disease-associati...

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Detalles Bibliográficos
Autores principales: Galhardo, Mafalda, Berninger, Philipp, Nguyen, Thanh-Phuong, Sauter, Thomas, Sinkkonen, Lasse
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605313/
https://www.ncbi.nlm.nih.gov/pubmed/26338775
http://dx.doi.org/10.1093/nar/gkv863

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605313/
https://www.ncbi.nlm.nih.gov/pubmed/26338775
http://dx.doi.org/10.1093/nar/gkv863

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