Structure and specificity of the RNA-guided endonuclease Cas9 during DNA interrogation, target binding and cleavage

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CRISPR-associated endonuclease Cas9 cuts DNA at variable target sites designated by a Cas9-bound RNA molecule. Cas9's ability to be directed by single ‘guide RNA’ molecules to target nearly any sequence has been recently exploited for a number of emerging biological and medical applications. Th...

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Detalles Bibliográficos
Autores principales: Josephs, Eric A., Kocak, D. Dewran, Fitzgibbon, Christopher J., McMenemy, Joshua, Gersbach, Charles A., Marszalek, Piotr E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605321/
https://www.ncbi.nlm.nih.gov/pubmed/26384421
http://dx.doi.org/10.1093/nar/gkv892
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