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The STAT3 HIES mutation is a gain-of-function mutation that activates genes via AGG-element carrying promoters

Cytokine or growth factor activated STAT3 undergoes multiple post-translational modifications, dimerization and translocation into nuclei, where it binds to serum-inducible element (SIE, ‘TTC(N3)GAA’)-bearing promoters to activate transcription. The STAT3 DNA binding domain (DBD, 320–494) mutation i...

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Detalles Bibliográficos
Autores principales:	Xu, Li, Ji, Jin-Jun, Le, Wangping, Xu, Yan S., Dou, Dandan, Pan, Jieli, Jiao, Yifeng, Zhong, Tianfei, Wu, Dehong, Wang, Yumei, Wen, Chengping, Xie, Guan-Qun, Yao, Feng, Zhao, Heng, Fan, Yong-Sheng, Chin, Y. Eugene
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605325/ https://www.ncbi.nlm.nih.gov/pubmed/26384563 http://dx.doi.org/10.1093/nar/gkv911

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