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Endothelial-Leukocyte Interaction in Severe Malaria: Beyond the Brain

Malaria is the most important parasitic disease worldwide, accounting for 1 million deaths each year. Severe malaria is a systemic illness characterized by dysfunction of brain tissue and of one or more peripheral organs as lungs and kidney. The most severe and most studied form of malaria is associ...

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Detalles Bibliográficos
Autores principales: Souza, Mariana C., Padua, Tatiana A., Henriques, Maria G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605361/
https://www.ncbi.nlm.nih.gov/pubmed/26491221
http://dx.doi.org/10.1155/2015/168937
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author Souza, Mariana C.
Padua, Tatiana A.
Henriques, Maria G.
author_facet Souza, Mariana C.
Padua, Tatiana A.
Henriques, Maria G.
author_sort Souza, Mariana C.
collection PubMed
description Malaria is the most important parasitic disease worldwide, accounting for 1 million deaths each year. Severe malaria is a systemic illness characterized by dysfunction of brain tissue and of one or more peripheral organs as lungs and kidney. The most severe and most studied form of malaria is associated with cerebral complications due to capillary congestion and the adhesion of infected erythrocytes, platelets, and leukocytes to brain vasculature. Thus, leukocyte rolling and adhesion in the brain vascular bed during severe malaria is singular and distinct from other models of inflammation. The leukocyte/endothelium interaction and neutrophil accumulation are also observed in the lungs. However, lung interactions differ from brain interactions, likely due to differences in the blood-brain barrier and blood-air barrier tight junction composition of the brain and lung endothelium. Here, we review the importance of endothelial dysfunction and the mechanism of leukocyte/endothelium interaction during severe malaria. Furthermore, we hypothesize a possible use of adjunctive therapies to antimalarial drugs that target the interaction between the leukocytes and the endothelium.
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spelling pubmed-46053612015-10-21 Endothelial-Leukocyte Interaction in Severe Malaria: Beyond the Brain Souza, Mariana C. Padua, Tatiana A. Henriques, Maria G. Mediators Inflamm Review Article Malaria is the most important parasitic disease worldwide, accounting for 1 million deaths each year. Severe malaria is a systemic illness characterized by dysfunction of brain tissue and of one or more peripheral organs as lungs and kidney. The most severe and most studied form of malaria is associated with cerebral complications due to capillary congestion and the adhesion of infected erythrocytes, platelets, and leukocytes to brain vasculature. Thus, leukocyte rolling and adhesion in the brain vascular bed during severe malaria is singular and distinct from other models of inflammation. The leukocyte/endothelium interaction and neutrophil accumulation are also observed in the lungs. However, lung interactions differ from brain interactions, likely due to differences in the blood-brain barrier and blood-air barrier tight junction composition of the brain and lung endothelium. Here, we review the importance of endothelial dysfunction and the mechanism of leukocyte/endothelium interaction during severe malaria. Furthermore, we hypothesize a possible use of adjunctive therapies to antimalarial drugs that target the interaction between the leukocytes and the endothelium. Hindawi Publishing Corporation 2015 2015-09-30 /pmc/articles/PMC4605361/ /pubmed/26491221 http://dx.doi.org/10.1155/2015/168937 Text en Copyright © 2015 Mariana C. Souza et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Souza, Mariana C.
Padua, Tatiana A.
Henriques, Maria G.
Endothelial-Leukocyte Interaction in Severe Malaria: Beyond the Brain
title Endothelial-Leukocyte Interaction in Severe Malaria: Beyond the Brain
title_full Endothelial-Leukocyte Interaction in Severe Malaria: Beyond the Brain
title_fullStr Endothelial-Leukocyte Interaction in Severe Malaria: Beyond the Brain
title_full_unstemmed Endothelial-Leukocyte Interaction in Severe Malaria: Beyond the Brain
title_short Endothelial-Leukocyte Interaction in Severe Malaria: Beyond the Brain
title_sort endothelial-leukocyte interaction in severe malaria: beyond the brain
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605361/
https://www.ncbi.nlm.nih.gov/pubmed/26491221
http://dx.doi.org/10.1155/2015/168937
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