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Viral and atypical bacterial aetiologies of infection in hospitalised patients admitted with clinical suspicion of influenza in Thailand, Vietnam and Indonesia
BACKGROUND: Influenza constitutes a leading cause of morbidity and mortality worldwide. There is limited information about the aetiology of infection presenting clinically as influenza in hospitalised adults and children in South-East Asia. Such data are important for future management of respirator...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Ltd
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605413/ https://www.ncbi.nlm.nih.gov/pubmed/25980749 http://dx.doi.org/10.1111/irv.12326 |
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author | Wertheim, Heiman F L Nadjm, Behzad Thomas, Sherine Malik, Suhud Nguyen, Diep Ngoc Thi Vu, Dung Viet Tien Van Nguyen, Kinh Van Nguyen, Chau Vinh Nguyen, Liem Thanh Tran, Sinh Thi Phung, Thuy Bich Thi Nguyen, Trung Vu Hien, Tran Tinh Nguyen, Uyen Hanh Taylor, Walter Truong, Khanh Huu Ha, Tuan Manh Chokephaibulkit, Kulkanya Farrar, Jeremy Wolbers, Marcel de Jong, Menno D van Doorn, H Rogier Puthavathana, Pilaipan |
author_facet | Wertheim, Heiman F L Nadjm, Behzad Thomas, Sherine Malik, Suhud Nguyen, Diep Ngoc Thi Vu, Dung Viet Tien Van Nguyen, Kinh Van Nguyen, Chau Vinh Nguyen, Liem Thanh Tran, Sinh Thi Phung, Thuy Bich Thi Nguyen, Trung Vu Hien, Tran Tinh Nguyen, Uyen Hanh Taylor, Walter Truong, Khanh Huu Ha, Tuan Manh Chokephaibulkit, Kulkanya Farrar, Jeremy Wolbers, Marcel de Jong, Menno D van Doorn, H Rogier Puthavathana, Pilaipan |
author_sort | Wertheim, Heiman F L |
collection | PubMed |
description | BACKGROUND: Influenza constitutes a leading cause of morbidity and mortality worldwide. There is limited information about the aetiology of infection presenting clinically as influenza in hospitalised adults and children in South-East Asia. Such data are important for future management of respiratory infections. OBJECTIVES: To describe the aetiology of infection presenting clinically as influenza in those hospitalised in South-East Asia. METHODS: Respiratory specimens archived from July 2008 to June 2009 from patients hospitalised with suspected influenza from Indonesia, Thailand and Vietnam were tested for respiratory viruses and atypical bacteria by polymerase chain reaction. RESULTS: A total of 1222 patients’ samples were tested. Of 1222, 776 patients (63·5%) were under the age of 5. Viruses detected included rhinoviruses in 229 of 1222 patients (18·7%), bocaviruses in 200 (16·4%), respiratory syncytial viruses in 144 (11·8%), parainfluenza viruses in 140 (11·5%; PIV1: 32; PIV2: 12; PIV3: 71; PIV4: 25), adenovirus in 102 (8·4%), influenza viruses in 93 (7·6%; influenza A: 77; influenza B: 16) and coronaviruses in 23 (1·8%; OC43: 14; E229: 9). Bacterial pathogens were Mycoplasma pneumoniae (n = 33, 2·7%), Chlamydophila psittaci (n = 2), C. pneumoniae (n = 1), Bordetella pertussis (n = 1) and Legionella pneumophila (n = 2). Overall, in-hospital case fatality rate was 29 of 1222 (2·4%). CONCLUSION: Respiratory viruses were the most commonly detected pathogens in patients hospitalised with a clinical suspicion of influenza. Rhinovirus was the most frequently detected virus, and M. pneumoniae, the most common atypical bacterium. The low number of detected influenza viruses demonstrates a low benefit for empirical oseltamivir therapy, unless during an influenza outbreak. |
format | Online Article Text |
id | pubmed-4605413 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | John Wiley & Sons, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-46054132015-11-01 Viral and atypical bacterial aetiologies of infection in hospitalised patients admitted with clinical suspicion of influenza in Thailand, Vietnam and Indonesia Wertheim, Heiman F L Nadjm, Behzad Thomas, Sherine Malik, Suhud Nguyen, Diep Ngoc Thi Vu, Dung Viet Tien Van Nguyen, Kinh Van Nguyen, Chau Vinh Nguyen, Liem Thanh Tran, Sinh Thi Phung, Thuy Bich Thi Nguyen, Trung Vu Hien, Tran Tinh Nguyen, Uyen Hanh Taylor, Walter Truong, Khanh Huu Ha, Tuan Manh Chokephaibulkit, Kulkanya Farrar, Jeremy Wolbers, Marcel de Jong, Menno D van Doorn, H Rogier Puthavathana, Pilaipan Influenza Other Respir Viruses Original Articles BACKGROUND: Influenza constitutes a leading cause of morbidity and mortality worldwide. There is limited information about the aetiology of infection presenting clinically as influenza in hospitalised adults and children in South-East Asia. Such data are important for future management of respiratory infections. OBJECTIVES: To describe the aetiology of infection presenting clinically as influenza in those hospitalised in South-East Asia. METHODS: Respiratory specimens archived from July 2008 to June 2009 from patients hospitalised with suspected influenza from Indonesia, Thailand and Vietnam were tested for respiratory viruses and atypical bacteria by polymerase chain reaction. RESULTS: A total of 1222 patients’ samples were tested. Of 1222, 776 patients (63·5%) were under the age of 5. Viruses detected included rhinoviruses in 229 of 1222 patients (18·7%), bocaviruses in 200 (16·4%), respiratory syncytial viruses in 144 (11·8%), parainfluenza viruses in 140 (11·5%; PIV1: 32; PIV2: 12; PIV3: 71; PIV4: 25), adenovirus in 102 (8·4%), influenza viruses in 93 (7·6%; influenza A: 77; influenza B: 16) and coronaviruses in 23 (1·8%; OC43: 14; E229: 9). Bacterial pathogens were Mycoplasma pneumoniae (n = 33, 2·7%), Chlamydophila psittaci (n = 2), C. pneumoniae (n = 1), Bordetella pertussis (n = 1) and Legionella pneumophila (n = 2). Overall, in-hospital case fatality rate was 29 of 1222 (2·4%). CONCLUSION: Respiratory viruses were the most commonly detected pathogens in patients hospitalised with a clinical suspicion of influenza. Rhinovirus was the most frequently detected virus, and M. pneumoniae, the most common atypical bacterium. The low number of detected influenza viruses demonstrates a low benefit for empirical oseltamivir therapy, unless during an influenza outbreak. John Wiley & Sons, Ltd 2015-11 2015-10-13 /pmc/articles/PMC4605413/ /pubmed/25980749 http://dx.doi.org/10.1111/irv.12326 Text en © 2015 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Wertheim, Heiman F L Nadjm, Behzad Thomas, Sherine Malik, Suhud Nguyen, Diep Ngoc Thi Vu, Dung Viet Tien Van Nguyen, Kinh Van Nguyen, Chau Vinh Nguyen, Liem Thanh Tran, Sinh Thi Phung, Thuy Bich Thi Nguyen, Trung Vu Hien, Tran Tinh Nguyen, Uyen Hanh Taylor, Walter Truong, Khanh Huu Ha, Tuan Manh Chokephaibulkit, Kulkanya Farrar, Jeremy Wolbers, Marcel de Jong, Menno D van Doorn, H Rogier Puthavathana, Pilaipan Viral and atypical bacterial aetiologies of infection in hospitalised patients admitted with clinical suspicion of influenza in Thailand, Vietnam and Indonesia |
title | Viral and atypical bacterial aetiologies of infection in hospitalised patients admitted with clinical suspicion of influenza in Thailand, Vietnam and Indonesia |
title_full | Viral and atypical bacterial aetiologies of infection in hospitalised patients admitted with clinical suspicion of influenza in Thailand, Vietnam and Indonesia |
title_fullStr | Viral and atypical bacterial aetiologies of infection in hospitalised patients admitted with clinical suspicion of influenza in Thailand, Vietnam and Indonesia |
title_full_unstemmed | Viral and atypical bacterial aetiologies of infection in hospitalised patients admitted with clinical suspicion of influenza in Thailand, Vietnam and Indonesia |
title_short | Viral and atypical bacterial aetiologies of infection in hospitalised patients admitted with clinical suspicion of influenza in Thailand, Vietnam and Indonesia |
title_sort | viral and atypical bacterial aetiologies of infection in hospitalised patients admitted with clinical suspicion of influenza in thailand, vietnam and indonesia |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605413/ https://www.ncbi.nlm.nih.gov/pubmed/25980749 http://dx.doi.org/10.1111/irv.12326 |
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