A Randomized 2x2 Factorial Clinical Trial of Renal Transplantation: Steroid-Free Maintenance Immunosuppression with Calcineurin Inhibitor Withdrawal after Six Months Associates with Improved Renal Function and Reduced Chronic Histopathology

INTRODUCTION: The two most significant impediments to renal allograft survival are rejection and the direct nephrotoxicity of the immunosuppressant drugs required to prevent it. Calcineurin inhibitors (CNI), a mainstay of most immunosuppression regimens, are particularly nephrotoxic. Until less toxi...

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Detalles Bibliográficos
Autores principales: Stevens, R. Brian, Foster, Kirk W., Miles, Clifford D., Kalil, Andre C., Florescu, Diana F., Sandoz, John P., Rigley, Theodore H., Malik, Tamer, Wrenshall, Lucile E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605789/
https://www.ncbi.nlm.nih.gov/pubmed/26465152
http://dx.doi.org/10.1371/journal.pone.0139247

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