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Dexamethasone, tetrahydrobiopterin and uncoupling of endothelial nitric oxide synthase

OBJECTIVE: To find out whether dexamethasone induces an uncoupling of the endothelial nitric oxide synthase (eNOS). METHODS & RESULTS: A major cause of eNOS uncoupling is a deficiency of its cofactor tetrahydrobiopterin (BH(4)). Treatment of human EA.hy 926 endothelial cells with dexamethasone d...

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Detalles Bibliográficos
Autores principales:	Tobias, Silke, Habermeier, Alice, Siuda, Daniel, Reifenberg, Gisela, Xia, Ning, Closs, Ellen I, Förstermann, Ulrich, Li, Huige
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Science Press 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605949/ https://www.ncbi.nlm.nih.gov/pubmed/26512245 http://dx.doi.org/10.11909/j.issn.1671-5411.2015.05.013

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