Impact of miRNAs on cardiovascular aging

Aging is a multidimensional process that leads to an increased risk of developing severe diseases, such as cancer and cardiovascular, neurodegenerative, and immunological diseases. Recently, small non-coding RNAs known as microRNAs (miRNAs) have been shown to regulate gene expression, which contribu...

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Autores principales: Lee, Seahyoung, Choi, Eunhyun, Cha, Min-Ji, Park, Ae-Jun, Yoon, Cheesoon, Hwang, Ki-Chul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Science Press 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605953/
https://www.ncbi.nlm.nih.gov/pubmed/26512249
http://dx.doi.org/10.11909/j.issn.1671-5411.2015.05.011
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author Lee, Seahyoung
Choi, Eunhyun
Cha, Min-Ji
Park, Ae-Jun
Yoon, Cheesoon
Hwang, Ki-Chul
author_facet Lee, Seahyoung
Choi, Eunhyun
Cha, Min-Ji
Park, Ae-Jun
Yoon, Cheesoon
Hwang, Ki-Chul
author_sort Lee, Seahyoung
collection PubMed
description Aging is a multidimensional process that leads to an increased risk of developing severe diseases, such as cancer and cardiovascular, neurodegenerative, and immunological diseases. Recently, small non-coding RNAs known as microRNAs (miRNAs) have been shown to regulate gene expression, which contributes to many physiological and pathophysiological processes in humans. Increasing evidence suggests that changes in miRNA expression profiles contribute to cellular senescence, aging and aging-related diseases. However, only a few miRNAs whose functions have been elucidated have been associated with aging and/or aging-related diseases. This article reviews the currently available findings regarding the roles of aging-related miRNAs, with a focus on cardiac and cardiovascular aging.
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spelling pubmed-46059532015-10-28 Impact of miRNAs on cardiovascular aging Lee, Seahyoung Choi, Eunhyun Cha, Min-Ji Park, Ae-Jun Yoon, Cheesoon Hwang, Ki-Chul J Geriatr Cardiol Review Aging is a multidimensional process that leads to an increased risk of developing severe diseases, such as cancer and cardiovascular, neurodegenerative, and immunological diseases. Recently, small non-coding RNAs known as microRNAs (miRNAs) have been shown to regulate gene expression, which contributes to many physiological and pathophysiological processes in humans. Increasing evidence suggests that changes in miRNA expression profiles contribute to cellular senescence, aging and aging-related diseases. However, only a few miRNAs whose functions have been elucidated have been associated with aging and/or aging-related diseases. This article reviews the currently available findings regarding the roles of aging-related miRNAs, with a focus on cardiac and cardiovascular aging. Science Press 2015-09 /pmc/articles/PMC4605953/ /pubmed/26512249 http://dx.doi.org/10.11909/j.issn.1671-5411.2015.05.011 Text en Institute of Geriatric Cardiology http://creativecommons.org/licenses/by-nc-sa/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resulting work under the same or similar license to this one. The work must be attributed back to the original author and commercial use is not permitted without specific permission.
spellingShingle Review
Lee, Seahyoung
Choi, Eunhyun
Cha, Min-Ji
Park, Ae-Jun
Yoon, Cheesoon
Hwang, Ki-Chul
Impact of miRNAs on cardiovascular aging
title Impact of miRNAs on cardiovascular aging
title_full Impact of miRNAs on cardiovascular aging
title_fullStr Impact of miRNAs on cardiovascular aging
title_full_unstemmed Impact of miRNAs on cardiovascular aging
title_short Impact of miRNAs on cardiovascular aging
title_sort impact of mirnas on cardiovascular aging
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605953/
https://www.ncbi.nlm.nih.gov/pubmed/26512249
http://dx.doi.org/10.11909/j.issn.1671-5411.2015.05.011
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AT chaminji impactofmirnasoncardiovascularaging
AT parkaejun impactofmirnasoncardiovascularaging
AT yooncheesoon impactofmirnasoncardiovascularaging
AT hwangkichul impactofmirnasoncardiovascularaging

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