Dynamic of plasmodium falciparum chloroquine resistance transporter gene Pfcrt K76T mutation five years after withdrawal of chloroquine in Burkina Faso

We investigated the evolution of Pfcrt K76T mutation five years after the withdrawal of chloroquine in Burkina Faso. A total of 675 clinical isolates collected from October 2010 to September 2012 were successfully genotyped. Single nucleotide polymorphism in Pfcrt (codon 76) gene was analyzed. The p...

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Autores principales: Sondo, Paul, Derra, Karim, Tarnagda, Zekiba, Nakanabo, Seydou Diallo, Zampa, Odile, Kazienga, Adama, Valea, Innocent, Sorgho, Hermann, Ouedraogo, Jean-Bosco, Guiguemde, Tinga Robert, Tinto, Halidou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The African Field Epidemiology Network 2015
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4606025/
https://www.ncbi.nlm.nih.gov/pubmed/26516402
http://dx.doi.org/10.11604/pamj.2015.21.101.6437
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author Sondo, Paul
Derra, Karim
Tarnagda, Zekiba
Nakanabo, Seydou Diallo
Zampa, Odile
Kazienga, Adama
Valea, Innocent
Sorgho, Hermann
Ouedraogo, Jean-Bosco
Guiguemde, Tinga Robert
Tinto, Halidou
author_facet Sondo, Paul
Derra, Karim
Tarnagda, Zekiba
Nakanabo, Seydou Diallo
Zampa, Odile
Kazienga, Adama
Valea, Innocent
Sorgho, Hermann
Ouedraogo, Jean-Bosco
Guiguemde, Tinga Robert
Tinto, Halidou
author_sort Sondo, Paul
collection PubMed
description We investigated the evolution of Pfcrt K76T mutation five years after the withdrawal of chloroquine in Burkina Faso. A total of 675 clinical isolates collected from October 2010 to September 2012 were successfully genotyped. Single nucleotide polymorphism in Pfcrt (codon 76) gene was analyzed. The prevalence of resistant Pfcrt 76T allele was 20.55%. There was a progressive decrease of the proportion of mutant type pfcrt T76 from 2010 to 2012 (X2=5.508 p=0.0189). Our results suggest a progressive return of the wild type Pfcrt K76 in Burkina Faso but the prevalence of the mutants Pfcrt T76 still remains high.
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spelling pubmed-46060252015-10-29 Dynamic of plasmodium falciparum chloroquine resistance transporter gene Pfcrt K76T mutation five years after withdrawal of chloroquine in Burkina Faso Sondo, Paul Derra, Karim Tarnagda, Zekiba Nakanabo, Seydou Diallo Zampa, Odile Kazienga, Adama Valea, Innocent Sorgho, Hermann Ouedraogo, Jean-Bosco Guiguemde, Tinga Robert Tinto, Halidou Pan Afr Med J Short Communication We investigated the evolution of Pfcrt K76T mutation five years after the withdrawal of chloroquine in Burkina Faso. A total of 675 clinical isolates collected from October 2010 to September 2012 were successfully genotyped. Single nucleotide polymorphism in Pfcrt (codon 76) gene was analyzed. The prevalence of resistant Pfcrt 76T allele was 20.55%. There was a progressive decrease of the proportion of mutant type pfcrt T76 from 2010 to 2012 (X2=5.508 p=0.0189). Our results suggest a progressive return of the wild type Pfcrt K76 in Burkina Faso but the prevalence of the mutants Pfcrt T76 still remains high. The African Field Epidemiology Network 2015-06-09 /pmc/articles/PMC4606025/ /pubmed/26516402 http://dx.doi.org/10.11604/pamj.2015.21.101.6437 Text en © Paul Sondo et al. http://creativecommons.org/licenses/by/2.0/ The Pan African Medical Journal - ISSN 1937-8688. This is an Open Access article distributed under the terms of the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Sondo, Paul
Derra, Karim
Tarnagda, Zekiba
Nakanabo, Seydou Diallo
Zampa, Odile
Kazienga, Adama
Valea, Innocent
Sorgho, Hermann
Ouedraogo, Jean-Bosco
Guiguemde, Tinga Robert
Tinto, Halidou
Dynamic of plasmodium falciparum chloroquine resistance transporter gene Pfcrt K76T mutation five years after withdrawal of chloroquine in Burkina Faso
title Dynamic of plasmodium falciparum chloroquine resistance transporter gene Pfcrt K76T mutation five years after withdrawal of chloroquine in Burkina Faso
title_full Dynamic of plasmodium falciparum chloroquine resistance transporter gene Pfcrt K76T mutation five years after withdrawal of chloroquine in Burkina Faso
title_fullStr Dynamic of plasmodium falciparum chloroquine resistance transporter gene Pfcrt K76T mutation five years after withdrawal of chloroquine in Burkina Faso
title_full_unstemmed Dynamic of plasmodium falciparum chloroquine resistance transporter gene Pfcrt K76T mutation five years after withdrawal of chloroquine in Burkina Faso
title_short Dynamic of plasmodium falciparum chloroquine resistance transporter gene Pfcrt K76T mutation five years after withdrawal of chloroquine in Burkina Faso
title_sort dynamic of plasmodium falciparum chloroquine resistance transporter gene pfcrt k76t mutation five years after withdrawal of chloroquine in burkina faso
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4606025/
https://www.ncbi.nlm.nih.gov/pubmed/26516402
http://dx.doi.org/10.11604/pamj.2015.21.101.6437
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