New Developments in Peritoneal Fibroblast Biology: Implications for Inflammation and Fibrosis in Peritoneal Dialysis

Uraemia and long-term peritoneal dialysis (PD) can lead to fibrotic thickening of the peritoneal membrane, which may limit its dialytic function. Peritoneal fibrosis is associated with the appearance of myofibroblasts and expansion of extracellular matrix. The extent of contribution of resident peri...

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Detalles Bibliográficos
Autores principales: Witowski, Janusz, Kawka, Edyta, Rudolf, Andras, Jörres, Achim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4606153/
https://www.ncbi.nlm.nih.gov/pubmed/26495280
http://dx.doi.org/10.1155/2015/134708
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author Witowski, Janusz
Kawka, Edyta
Rudolf, Andras
Jörres, Achim
author_facet Witowski, Janusz
Kawka, Edyta
Rudolf, Andras
Jörres, Achim
author_sort Witowski, Janusz
collection PubMed
description Uraemia and long-term peritoneal dialysis (PD) can lead to fibrotic thickening of the peritoneal membrane, which may limit its dialytic function. Peritoneal fibrosis is associated with the appearance of myofibroblasts and expansion of extracellular matrix. The extent of contribution of resident peritoneal fibroblasts to these changes is a matter of debate. Recent studies point to a significant heterogeneity and complexity of the peritoneal fibroblast population. Here, we review recent developments in peritoneal fibroblast biology and summarize the current knowledge on the involvement of peritoneal fibroblasts in peritoneal inflammation and fibrosis.
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spelling pubmed-46061532015-10-22 New Developments in Peritoneal Fibroblast Biology: Implications for Inflammation and Fibrosis in Peritoneal Dialysis Witowski, Janusz Kawka, Edyta Rudolf, Andras Jörres, Achim Biomed Res Int Review Article Uraemia and long-term peritoneal dialysis (PD) can lead to fibrotic thickening of the peritoneal membrane, which may limit its dialytic function. Peritoneal fibrosis is associated with the appearance of myofibroblasts and expansion of extracellular matrix. The extent of contribution of resident peritoneal fibroblasts to these changes is a matter of debate. Recent studies point to a significant heterogeneity and complexity of the peritoneal fibroblast population. Here, we review recent developments in peritoneal fibroblast biology and summarize the current knowledge on the involvement of peritoneal fibroblasts in peritoneal inflammation and fibrosis. Hindawi Publishing Corporation 2015 2015-10-01 /pmc/articles/PMC4606153/ /pubmed/26495280 http://dx.doi.org/10.1155/2015/134708 Text en Copyright © 2015 Janusz Witowski et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Witowski, Janusz
Kawka, Edyta
Rudolf, Andras
Jörres, Achim
New Developments in Peritoneal Fibroblast Biology: Implications for Inflammation and Fibrosis in Peritoneal Dialysis
title New Developments in Peritoneal Fibroblast Biology: Implications for Inflammation and Fibrosis in Peritoneal Dialysis
title_full New Developments in Peritoneal Fibroblast Biology: Implications for Inflammation and Fibrosis in Peritoneal Dialysis
title_fullStr New Developments in Peritoneal Fibroblast Biology: Implications for Inflammation and Fibrosis in Peritoneal Dialysis
title_full_unstemmed New Developments in Peritoneal Fibroblast Biology: Implications for Inflammation and Fibrosis in Peritoneal Dialysis
title_short New Developments in Peritoneal Fibroblast Biology: Implications for Inflammation and Fibrosis in Peritoneal Dialysis
title_sort new developments in peritoneal fibroblast biology: implications for inflammation and fibrosis in peritoneal dialysis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4606153/
https://www.ncbi.nlm.nih.gov/pubmed/26495280
http://dx.doi.org/10.1155/2015/134708
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