The Effects of Chinese Medicine on Activation of Wnt/β-Catenin Signal Pathway under High Glucose Condition

Diabetes mellitus (DM) is a metabolic disease characterized by chronic hyperglycemia and a series of complications. The Wnt/β-catenin signaling pathway is a complex protein interaction network, which is also a key regulator of cell proliferation and differentiation. Many scholars have found that hig...

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Detalles Bibliográficos
Autores principales: Liu, Wei, Liang, Xiaochun, Yang, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4606185/
https://www.ncbi.nlm.nih.gov/pubmed/26495008
http://dx.doi.org/10.1155/2015/295135
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author Liu, Wei
Liang, Xiaochun
Yang, Dan
author_facet Liu, Wei
Liang, Xiaochun
Yang, Dan
author_sort Liu, Wei
collection PubMed
description Diabetes mellitus (DM) is a metabolic disease characterized by chronic hyperglycemia and a series of complications. The Wnt/β-catenin signaling pathway is a complex protein interaction network, which is also a key regulator of cell proliferation and differentiation. Many scholars have found that high glucose can activate the Wnt signaling pathway. However, the effects of activation of this pathway in the presence of high glucose levels during the progression of diabetes still remained unclear. Here, we provide a review of the study on the effects of high glucose state on the Wnt/β-catenin signal pathway and the influence of Chinese medicine on it.
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spelling pubmed-46061852015-10-22 The Effects of Chinese Medicine on Activation of Wnt/β-Catenin Signal Pathway under High Glucose Condition Liu, Wei Liang, Xiaochun Yang, Dan Evid Based Complement Alternat Med Review Article Diabetes mellitus (DM) is a metabolic disease characterized by chronic hyperglycemia and a series of complications. The Wnt/β-catenin signaling pathway is a complex protein interaction network, which is also a key regulator of cell proliferation and differentiation. Many scholars have found that high glucose can activate the Wnt signaling pathway. However, the effects of activation of this pathway in the presence of high glucose levels during the progression of diabetes still remained unclear. Here, we provide a review of the study on the effects of high glucose state on the Wnt/β-catenin signal pathway and the influence of Chinese medicine on it. Hindawi Publishing Corporation 2015 2015-10-01 /pmc/articles/PMC4606185/ /pubmed/26495008 http://dx.doi.org/10.1155/2015/295135 Text en Copyright © 2015 Wei Liu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Liu, Wei
Liang, Xiaochun
Yang, Dan
The Effects of Chinese Medicine on Activation of Wnt/β-Catenin Signal Pathway under High Glucose Condition
title The Effects of Chinese Medicine on Activation of Wnt/β-Catenin Signal Pathway under High Glucose Condition
title_full The Effects of Chinese Medicine on Activation of Wnt/β-Catenin Signal Pathway under High Glucose Condition
title_fullStr The Effects of Chinese Medicine on Activation of Wnt/β-Catenin Signal Pathway under High Glucose Condition
title_full_unstemmed The Effects of Chinese Medicine on Activation of Wnt/β-Catenin Signal Pathway under High Glucose Condition
title_short The Effects of Chinese Medicine on Activation of Wnt/β-Catenin Signal Pathway under High Glucose Condition
title_sort effects of chinese medicine on activation of wnt/β-catenin signal pathway under high glucose condition
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4606185/
https://www.ncbi.nlm.nih.gov/pubmed/26495008
http://dx.doi.org/10.1155/2015/295135
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