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Guided Tissue Regeneration in Heart Valve Replacement: From Preclinical Research to First-in-Human Trials
Heart valve tissue-guided regeneration aims to offer a functional and viable alternative to current prosthetic replacements. Not requiring previous cell seeding and conditioning in bioreactors, such exceptional tissue engineering approach is a very fascinating translational regenerative strategy. Af...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4606187/ https://www.ncbi.nlm.nih.gov/pubmed/26495295 http://dx.doi.org/10.1155/2015/432901 |
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author | Iop, L. Gerosa, G. |
author_facet | Iop, L. Gerosa, G. |
author_sort | Iop, L. |
collection | PubMed |
description | Heart valve tissue-guided regeneration aims to offer a functional and viable alternative to current prosthetic replacements. Not requiring previous cell seeding and conditioning in bioreactors, such exceptional tissue engineering approach is a very fascinating translational regenerative strategy. After in vivo implantation, decellularized heart valve scaffolds drive their same repopulation by recipient's cells for a prospective autologous-like tissue reconstruction, remodeling, and adaptation to the somatic growth of the patient. With such a viability, tissue-guided regenerated conduits can be delivered as off-the-shelf biodevices and possess all the potentialities for a long-lasting resolution of the dramatic inconvenience of heart valve diseases, both in children and in the elderly. A review on preclinical and clinical investigations of this therapeutic concept is provided with evaluation of the issues still to be well deliberated for an effective and safe in-human application. |
format | Online Article Text |
id | pubmed-4606187 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-46061872015-10-22 Guided Tissue Regeneration in Heart Valve Replacement: From Preclinical Research to First-in-Human Trials Iop, L. Gerosa, G. Biomed Res Int Review Article Heart valve tissue-guided regeneration aims to offer a functional and viable alternative to current prosthetic replacements. Not requiring previous cell seeding and conditioning in bioreactors, such exceptional tissue engineering approach is a very fascinating translational regenerative strategy. After in vivo implantation, decellularized heart valve scaffolds drive their same repopulation by recipient's cells for a prospective autologous-like tissue reconstruction, remodeling, and adaptation to the somatic growth of the patient. With such a viability, tissue-guided regenerated conduits can be delivered as off-the-shelf biodevices and possess all the potentialities for a long-lasting resolution of the dramatic inconvenience of heart valve diseases, both in children and in the elderly. A review on preclinical and clinical investigations of this therapeutic concept is provided with evaluation of the issues still to be well deliberated for an effective and safe in-human application. Hindawi Publishing Corporation 2015 2015-10-01 /pmc/articles/PMC4606187/ /pubmed/26495295 http://dx.doi.org/10.1155/2015/432901 Text en Copyright © 2015 L. Iop and G. Gerosa. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Iop, L. Gerosa, G. Guided Tissue Regeneration in Heart Valve Replacement: From Preclinical Research to First-in-Human Trials |
title | Guided Tissue Regeneration in Heart Valve Replacement: From Preclinical Research to First-in-Human Trials |
title_full | Guided Tissue Regeneration in Heart Valve Replacement: From Preclinical Research to First-in-Human Trials |
title_fullStr | Guided Tissue Regeneration in Heart Valve Replacement: From Preclinical Research to First-in-Human Trials |
title_full_unstemmed | Guided Tissue Regeneration in Heart Valve Replacement: From Preclinical Research to First-in-Human Trials |
title_short | Guided Tissue Regeneration in Heart Valve Replacement: From Preclinical Research to First-in-Human Trials |
title_sort | guided tissue regeneration in heart valve replacement: from preclinical research to first-in-human trials |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4606187/ https://www.ncbi.nlm.nih.gov/pubmed/26495295 http://dx.doi.org/10.1155/2015/432901 |
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