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Virological Mechanisms in the Coinfection between HIV and HCV
Due to shared transmission routes, coinfection with Hepatitis C Virus (HCV) is common in patients infected by Human Immunodeficiency Virus (HIV). The immune-pathogenesis of liver disease in HIV/HCV coinfected patients is a multifactorial process. Several studies demonstrated that HIV worsens the cou...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4606210/ https://www.ncbi.nlm.nih.gov/pubmed/26494946 http://dx.doi.org/10.1155/2015/320532 |
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author | Liberto, Maria Carla Zicca, Emilia Pavia, Grazia Quirino, Angela Marascio, Nadia Torti, Carlo Focà, Alfredo |
author_facet | Liberto, Maria Carla Zicca, Emilia Pavia, Grazia Quirino, Angela Marascio, Nadia Torti, Carlo Focà, Alfredo |
author_sort | Liberto, Maria Carla |
collection | PubMed |
description | Due to shared transmission routes, coinfection with Hepatitis C Virus (HCV) is common in patients infected by Human Immunodeficiency Virus (HIV). The immune-pathogenesis of liver disease in HIV/HCV coinfected patients is a multifactorial process. Several studies demonstrated that HIV worsens the course of HCV infection, increasing the risk of cirrhosis and hepatocellular carcinoma. Also, HCV might increase immunological defects due to HIV and risk of comorbidities. A specific cross-talk among HIV and HCV proteins in coinfected patients modulates the natural history, the immune responses, and the life cycle of both viruses. These effects are mediated by immune mechanisms and by a cross-talk between the two viruses which could interfere with host defense mechanisms. In this review, we focus on some virological/immunological mechanisms of the pathogenetic interactions between HIV and HCV in the human host. |
format | Online Article Text |
id | pubmed-4606210 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-46062102015-10-22 Virological Mechanisms in the Coinfection between HIV and HCV Liberto, Maria Carla Zicca, Emilia Pavia, Grazia Quirino, Angela Marascio, Nadia Torti, Carlo Focà, Alfredo Mediators Inflamm Review Article Due to shared transmission routes, coinfection with Hepatitis C Virus (HCV) is common in patients infected by Human Immunodeficiency Virus (HIV). The immune-pathogenesis of liver disease in HIV/HCV coinfected patients is a multifactorial process. Several studies demonstrated that HIV worsens the course of HCV infection, increasing the risk of cirrhosis and hepatocellular carcinoma. Also, HCV might increase immunological defects due to HIV and risk of comorbidities. A specific cross-talk among HIV and HCV proteins in coinfected patients modulates the natural history, the immune responses, and the life cycle of both viruses. These effects are mediated by immune mechanisms and by a cross-talk between the two viruses which could interfere with host defense mechanisms. In this review, we focus on some virological/immunological mechanisms of the pathogenetic interactions between HIV and HCV in the human host. Hindawi Publishing Corporation 2015 2015-10-01 /pmc/articles/PMC4606210/ /pubmed/26494946 http://dx.doi.org/10.1155/2015/320532 Text en Copyright © 2015 Maria Carla Liberto et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Liberto, Maria Carla Zicca, Emilia Pavia, Grazia Quirino, Angela Marascio, Nadia Torti, Carlo Focà, Alfredo Virological Mechanisms in the Coinfection between HIV and HCV |
title | Virological Mechanisms in the Coinfection between HIV and HCV |
title_full | Virological Mechanisms in the Coinfection between HIV and HCV |
title_fullStr | Virological Mechanisms in the Coinfection between HIV and HCV |
title_full_unstemmed | Virological Mechanisms in the Coinfection between HIV and HCV |
title_short | Virological Mechanisms in the Coinfection between HIV and HCV |
title_sort | virological mechanisms in the coinfection between hiv and hcv |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4606210/ https://www.ncbi.nlm.nih.gov/pubmed/26494946 http://dx.doi.org/10.1155/2015/320532 |
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