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Active Compounds of Rhubarb Root and Rhizome in Animal Model Experiments of Focal Cerebral Ischemia

Rhubarb root and rhizome (RRR) has been clinically used for stroke at least 2000 years and is still used in modern times in both China and elsewhere worldwide. The objective of present study was to evaluate the efficacy of active compounds of RRR (ACRRR) for experimental ischemic stroke. Studies of...

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Autores principales: Liu, Ai-ju, Song, Liang, Li, Yan, Zhang, Xiao-guang, Chen, Zi-xian, Huang, Li-bo, Zhang, Hong-feng, Zheng, Guo-qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4606211/
https://www.ncbi.nlm.nih.gov/pubmed/26495006
http://dx.doi.org/10.1155/2015/210546
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author Liu, Ai-ju
Song, Liang
Li, Yan
Zhang, Xiao-guang
Chen, Zi-xian
Huang, Li-bo
Zhang, Hong-feng
Zheng, Guo-qing
author_facet Liu, Ai-ju
Song, Liang
Li, Yan
Zhang, Xiao-guang
Chen, Zi-xian
Huang, Li-bo
Zhang, Hong-feng
Zheng, Guo-qing
author_sort Liu, Ai-ju
collection PubMed
description Rhubarb root and rhizome (RRR) has been clinically used for stroke at least 2000 years and is still used in modern times in both China and elsewhere worldwide. The objective of present study was to evaluate the efficacy of active compounds of RRR (ACRRR) for experimental ischemic stroke. Studies of ACRRR in animal models of ischemic stroke were identified from 5 databases until April 2014. Study quality for each included article was evaluated according to the CAMARADES 10-item checklist. Outcome measures were neurological deficit score and infarct size. All the data were analyzed using RevMan 5.1 software. As a result, 20 studies were identified describing procedures involving 577 animals. The quality score of studies ranges from 2 to 6, and the median was 3.4. Six studies showed significant effects of ACRRR for improving infarct size compared with model group (P < 0.01). Six studies indicated significant effects of ACRRR for improving the neurological deficit scores according to Zea longa criterion or eight-point criterion (P < 0.01). In conclusion, these findings demonstrated a possible efficacy of ACRRR that have potential neuroprotective effect for experimental ischemic stroke. However, these apparently positive findings should be interpreted with caution because of the methodological flaws.
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spelling pubmed-46062112015-10-22 Active Compounds of Rhubarb Root and Rhizome in Animal Model Experiments of Focal Cerebral Ischemia Liu, Ai-ju Song, Liang Li, Yan Zhang, Xiao-guang Chen, Zi-xian Huang, Li-bo Zhang, Hong-feng Zheng, Guo-qing Evid Based Complement Alternat Med Research Article Rhubarb root and rhizome (RRR) has been clinically used for stroke at least 2000 years and is still used in modern times in both China and elsewhere worldwide. The objective of present study was to evaluate the efficacy of active compounds of RRR (ACRRR) for experimental ischemic stroke. Studies of ACRRR in animal models of ischemic stroke were identified from 5 databases until April 2014. Study quality for each included article was evaluated according to the CAMARADES 10-item checklist. Outcome measures were neurological deficit score and infarct size. All the data were analyzed using RevMan 5.1 software. As a result, 20 studies were identified describing procedures involving 577 animals. The quality score of studies ranges from 2 to 6, and the median was 3.4. Six studies showed significant effects of ACRRR for improving infarct size compared with model group (P < 0.01). Six studies indicated significant effects of ACRRR for improving the neurological deficit scores according to Zea longa criterion or eight-point criterion (P < 0.01). In conclusion, these findings demonstrated a possible efficacy of ACRRR that have potential neuroprotective effect for experimental ischemic stroke. However, these apparently positive findings should be interpreted with caution because of the methodological flaws. Hindawi Publishing Corporation 2015 2015-10-01 /pmc/articles/PMC4606211/ /pubmed/26495006 http://dx.doi.org/10.1155/2015/210546 Text en Copyright © 2015 Ai-ju Liu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Liu, Ai-ju
Song, Liang
Li, Yan
Zhang, Xiao-guang
Chen, Zi-xian
Huang, Li-bo
Zhang, Hong-feng
Zheng, Guo-qing
Active Compounds of Rhubarb Root and Rhizome in Animal Model Experiments of Focal Cerebral Ischemia
title Active Compounds of Rhubarb Root and Rhizome in Animal Model Experiments of Focal Cerebral Ischemia
title_full Active Compounds of Rhubarb Root and Rhizome in Animal Model Experiments of Focal Cerebral Ischemia
title_fullStr Active Compounds of Rhubarb Root and Rhizome in Animal Model Experiments of Focal Cerebral Ischemia
title_full_unstemmed Active Compounds of Rhubarb Root and Rhizome in Animal Model Experiments of Focal Cerebral Ischemia
title_short Active Compounds of Rhubarb Root and Rhizome in Animal Model Experiments of Focal Cerebral Ischemia
title_sort active compounds of rhubarb root and rhizome in animal model experiments of focal cerebral ischemia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4606211/
https://www.ncbi.nlm.nih.gov/pubmed/26495006
http://dx.doi.org/10.1155/2015/210546
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