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Computational Investigation of RNA CUG Repeats Responsible for Myotonic Dystrophy 1
[Image: see text] Myotonic Dystrophy 1 (DM1) is a genetic disease caused by expansion of CTG repeats in DNA. Once transcribed, these repeats form RNA hairpins with repeating 1×1 nucleotide UU internal loop motifs, r(CUG)(n), which attract muscleblind-like 1 (MBNL1) protein leading to the disease. In...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American
Chemical Society
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4606397/ https://www.ncbi.nlm.nih.gov/pubmed/26500461 http://dx.doi.org/10.1021/acs.jctc.5b00728 |