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Association between COX-2 gene polymorphisms and risk of hepatocellular carcinoma development: a meta-analysis

OBJECTIVE: To investigate the association between cyclo-oxygenase-2 (COX-2) polymorphism and the risk of hepatocellular carcinoma (HCC) development. DESIGN: Systematic review and meta-analysis of COX-2 polymorphism and risk of HCC development among people with or without HCC. DATA SOURCES: EMBASE, P...

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Autores principales: Lu, Si-Cong, Zhong, Jian-Hong, Tan, Jun-Tao, Tang, Hua-Lin, Liu, Xiao-Guang, Xiang, Bang-De, Li, Le-Qun, Peng, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4606424/
https://www.ncbi.nlm.nih.gov/pubmed/26438136
http://dx.doi.org/10.1136/bmjopen-2015-008263
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author Lu, Si-Cong
Zhong, Jian-Hong
Tan, Jun-Tao
Tang, Hua-Lin
Liu, Xiao-Guang
Xiang, Bang-De
Li, Le-Qun
Peng, Tao
author_facet Lu, Si-Cong
Zhong, Jian-Hong
Tan, Jun-Tao
Tang, Hua-Lin
Liu, Xiao-Guang
Xiang, Bang-De
Li, Le-Qun
Peng, Tao
author_sort Lu, Si-Cong
collection PubMed
description OBJECTIVE: To investigate the association between cyclo-oxygenase-2 (COX-2) polymorphism and the risk of hepatocellular carcinoma (HCC) development. DESIGN: Systematic review and meta-analysis of COX-2 polymorphism and risk of HCC development among people with or without HCC. DATA SOURCES: EMBASE, PubMed, Public Library of Science, SCOPUS, Web of Knowledge and Chinese National Knowledge Infrastructure were searched for all clinical and experimental case–control studies of COX-2 polymorphism and HCC risk. Studies published up to March 2015 were included. REVIEW METHOD: Ten studies were included for data extraction, which were mainly from Asian countries. RESULTS: 2538 people with HCC and 3714 without HCC were found to satisfy the inclusion criteria and included in the review. The associations of specific genotypes in the eight polymorphic variants of COX-2 and the risk of HCC development were analysed. GG genotype at the A-1195G polymorphism may be associated with a reduced risk of HCC development: the OR across all studies was 0.87 (95% CI 0.75 to 1.02) for the G allele versus the A allele, 0.72 (0.53 to 0.97) for GG versus AA, 0.72 (0.57 to 0.92) for GG versus GA+AA and 1.05 (0.77 to 1.44) for AA versus GA+GG. Similar results were found when the meta-analysis was repeated separately for the Chinese subgroup. However, more reliable data are needed to demonstrate associations between variants in G-765C, T+8473C, A-1290G, G-899C and introns 1, 5 and 6 polymorphisms and the risk of HCC development. CONCLUSIONS: Only the COX-2 A-1195G gene polymorphism may be associated with a decreased risk of HCC development. These conclusions should be verified in further studies.
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spelling pubmed-46064242015-10-22 Association between COX-2 gene polymorphisms and risk of hepatocellular carcinoma development: a meta-analysis Lu, Si-Cong Zhong, Jian-Hong Tan, Jun-Tao Tang, Hua-Lin Liu, Xiao-Guang Xiang, Bang-De Li, Le-Qun Peng, Tao BMJ Open Gastroenterology and Hepatology OBJECTIVE: To investigate the association between cyclo-oxygenase-2 (COX-2) polymorphism and the risk of hepatocellular carcinoma (HCC) development. DESIGN: Systematic review and meta-analysis of COX-2 polymorphism and risk of HCC development among people with or without HCC. DATA SOURCES: EMBASE, PubMed, Public Library of Science, SCOPUS, Web of Knowledge and Chinese National Knowledge Infrastructure were searched for all clinical and experimental case–control studies of COX-2 polymorphism and HCC risk. Studies published up to March 2015 were included. REVIEW METHOD: Ten studies were included for data extraction, which were mainly from Asian countries. RESULTS: 2538 people with HCC and 3714 without HCC were found to satisfy the inclusion criteria and included in the review. The associations of specific genotypes in the eight polymorphic variants of COX-2 and the risk of HCC development were analysed. GG genotype at the A-1195G polymorphism may be associated with a reduced risk of HCC development: the OR across all studies was 0.87 (95% CI 0.75 to 1.02) for the G allele versus the A allele, 0.72 (0.53 to 0.97) for GG versus AA, 0.72 (0.57 to 0.92) for GG versus GA+AA and 1.05 (0.77 to 1.44) for AA versus GA+GG. Similar results were found when the meta-analysis was repeated separately for the Chinese subgroup. However, more reliable data are needed to demonstrate associations between variants in G-765C, T+8473C, A-1290G, G-899C and introns 1, 5 and 6 polymorphisms and the risk of HCC development. CONCLUSIONS: Only the COX-2 A-1195G gene polymorphism may be associated with a decreased risk of HCC development. These conclusions should be verified in further studies. BMJ Publishing Group 2015-10-05 /pmc/articles/PMC4606424/ /pubmed/26438136 http://dx.doi.org/10.1136/bmjopen-2015-008263 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
spellingShingle Gastroenterology and Hepatology
Lu, Si-Cong
Zhong, Jian-Hong
Tan, Jun-Tao
Tang, Hua-Lin
Liu, Xiao-Guang
Xiang, Bang-De
Li, Le-Qun
Peng, Tao
Association between COX-2 gene polymorphisms and risk of hepatocellular carcinoma development: a meta-analysis
title Association between COX-2 gene polymorphisms and risk of hepatocellular carcinoma development: a meta-analysis
title_full Association between COX-2 gene polymorphisms and risk of hepatocellular carcinoma development: a meta-analysis
title_fullStr Association between COX-2 gene polymorphisms and risk of hepatocellular carcinoma development: a meta-analysis
title_full_unstemmed Association between COX-2 gene polymorphisms and risk of hepatocellular carcinoma development: a meta-analysis
title_short Association between COX-2 gene polymorphisms and risk of hepatocellular carcinoma development: a meta-analysis
title_sort association between cox-2 gene polymorphisms and risk of hepatocellular carcinoma development: a meta-analysis
topic Gastroenterology and Hepatology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4606424/
https://www.ncbi.nlm.nih.gov/pubmed/26438136
http://dx.doi.org/10.1136/bmjopen-2015-008263
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